Early exposure to ethanol is able to affect the memory of adult zebrafish: Possible role of adenosine

Neurotoxicology
Aline Haab LutteRosane Souza Da Silva

Abstract

Ethanol is one of the most widely consumed drugs in the world, and the effects of ethanol during early development include morphological and cognitive problems. The regulation of adenosine levels is essential for the proper function of major neurotransmitter systems in the brain, particularly glutamate and dopamine; thus, the investigation of the relation of adenosine and memory after early ethanol exposure becomes relevant. Embryos of zebrafish were exposed to 1% ethanol during two distinct developmental stages: gastrula/segmentation or pharyngula. The evaluation of memory, morphology, and locomotor parameters was performed when fish were 3 months old. The effect of ecto-5'-nucleotidase and adenosine deaminase inhibition on the consequences of ethanol exposure with regard to memory formation was observed. Morphological evaluation showed decreases in body length and the relative telencephalic and cerebellar areas in ethanol exposed animals. The locomotor parameters evaluated were not affected by ethanol. In the inhibitory avoidance paradigm, ethanol exposure during the gastrula/segmentation and pharyngula stages decreased zebrafish memory retention. When ethanol was given in the pharyngula stage, the inhibition of ecto-5'-nucle...Continue Reading

Citations

Jul 2, 2020·Biomedical Reports·Lianzhu ZhangZhengyao Zhang
Oct 23, 2020·Zebrafish·Nicholas Silvestre de Souza TrigueiroThiago Lopes Rocha
Mar 10, 2021·Neurotoxicity Research·Baban S Thawkar, Ginpreet Kaur
Apr 11, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jaquelinne Pinheiro-da-SilvaAna Carolina Luchiari

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