Early expression of negative/disorganized symptoms predicting psychotic experiences and subsequent clinical psychosis: a 10-year study

The American Journal of Psychiatry
Maria-de-Gracia DominguezJ van Os

Abstract

The cognitive and motivational impairments observed in psychotic disorders may reflect early developmental alterations that, when combined with later environmental exposures, may drive the onset of positive psychotic symptoms. The epidemiological predictions of this model were tested. A longitudinal prospective cohort study (the Early Developmental Stages of Psychopathology Study) was conducted with a representative general population sample of adolescents and young adults from Munich (N=3,021), who were 14-24 years of age at baseline. Sociodemographic factors, environmental exposures, and measures of psychopathology and associated clinical relevance were assessed across three waves, covering a period of up to 10 years, by clinical psychologists using the Composite International Diagnostic Interview. Both negative/disorganized and positive psychotic symptoms were frequent (5-year cumulative prevalence rates of around 12%) and occurred in combination more often than predicted by chance. Negative/disorganized symptoms revealed a pattern of sociodemographic associations indicative of developmental impairment, whereas the positive symptoms were associated with environmental exposures such as trauma, cannabis use, and urbanicity. Ne...Continue Reading

Citations

Jul 14, 2012·Epidemiology and Psychiatric Sciences·S SahaJ McGrath
Feb 26, 2014·Current Psychiatry Reports·Christian KohlerMonica E Calkins
Mar 4, 2014·Psychiatry Research·Christian G KohlerMonica E Calkins
Jun 4, 2014·Psychiatry Research·Eduardo Fonseca-PedreroJosé Muñiz
Jul 30, 2014·Psychological Medicine·E Bora
Jun 29, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Agna A Bartels-VelthuisDurk Wiersma
Jan 29, 2013·L'Encéphale·J-R Teyssier
Apr 11, 2015·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Monica E CalkinsRaquel E Gur
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Jun 22, 2013·International Journal of Methods in Psychiatric Research·Frank JacobiHans-Ulrich Wittchen
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Sep 5, 2012·Acta Psychiatrica Scandinavica·R NuevoJ L Ayuso-Mateos
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Jun 6, 2013·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Jim van OsMarieke Wichers
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Dec 31, 2014·Schizophrenia Bulletin·Martin DebbanéFrauke Schultze-Lutter
Oct 3, 2014·Psychological Medicine·T VelikonjaS Johnson

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