Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation

Proceedings of the National Academy of Sciences of the United States of America
Simona SivoriAlessandro Moretta

Abstract

In this study we analyzed the progression of cell surface receptor expression during the in vitro-induced human natural killer (NK) cell maturation from CD34(+) Lin(-) cell precursors. NKp46 and NKp30, two major triggering receptors that play a central role in natural cytotoxicity, were expressed before the HLA class I-specific inhibitory receptors. Moreover, their appearance at the cell surface correlated with the acquisition of cytolytic activity by developing NK cells. Although the early expression of triggering receptors may provide activating signals required for inducing further cell differentiation, it may also affect the self-tolerance of developing NK cells. Our data show that a fail-safe mechanism preventing killing of normal autologous cells may be provided by the 2B4 surface molecule, which, at early stages of NK cell differentiation, functions as an inhibitory rather than as an activating receptor.

References

Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·H G LjunggrenS Tonegawa
Oct 1, 1993·The Journal of Experimental Medicine·N M Valiante, G Trinchieri
Jan 1, 1996·Annual Review of Immunology·A MorettaL Moretta
Oct 7, 1997·The Journal of Experimental Medicine·S SivoriA Moretta
May 23, 1998·Annual Review of Immunology·L L Lanier
Jun 8, 1999·Annual Review of Immunology·E O Long
Mar 31, 2000·European Journal of Immunology·S SivoriA Moretta
Mar 13, 2001·Annual Review of Immunology·D H RauletC W McMahon
Mar 13, 2001·Annual Review of Immunology·M MorraC Terhorst
Mar 27, 2001·European Journal of Immunology·M VitaleA Moretta

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Citations

Jun 12, 2003·Developmental and Comparative Immunology·Trudy L HortonJohn D Horton
Jun 12, 2001·Molecular Immunology·R BiassoniA Moretta
Mar 14, 2003·Current Opinion in Immunology·Werner HeldJacques Zimmer
Dec 31, 2002·Microbes and Infection·Lorenzo MorettaAlessandro Moretta
Aug 30, 2002·Trends in Immunology·Andrea VelardiLorenzo Moretta
Jun 19, 2012·Cellular & Molecular Immunology·Martha LuevanoAurore Saudemont
Jan 20, 2009·Nature Immunology·Mario-Ernesto Cruz-MunozAndré Veillette
Aug 30, 2005·Nature Immunology·Romain RoncagalliAndré Veillette
Nov 5, 2002·Nature Reviews. Cancer·Mark J SmythHideo Yagita
Apr 21, 2005·Nature Reviews. Immunology·Vinay Kumar, Megan E McNerney
Sep 3, 2005·Nature Reviews. Immunology·Warren J Leonard, Rosanne Spolski
Feb 24, 2006·Nature Reviews. Immunology·André Veillette
Jun 27, 2006·Nature Reviews. Immunology·David H Raulet, Russell E Vance
Jan 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paola VaccaMaria Cristina Mingari
May 5, 2004·The Journal of Experimental Medicine·Kyung-Mi LeeVinay Kumar
May 5, 2004·The Journal of Experimental Medicine·André Veillette
Jul 17, 2004·Transplantation·Neil T Young
Mar 20, 2010·Cold Spring Harbor Perspectives in Biology·André Veillette
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Elena A Ostrakhovitch, Shawn S-C Li
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Mar 23, 2006·Annual Review of Immunology·Bianca Blom, Hergen Spits
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thierry WalzerEric Vivier
Jan 12, 2011·Annual Review of Immunology·Jennifer L CannonsPamela L Schwartzberg
Sep 6, 2011·Trends in Immunology·Paola VaccaMaria Cristina Mingari
Jan 19, 2010·Human Immunology·Xiaoyin NiuGuangjie Chen
Feb 6, 2014·European Journal of Immunology·Raffaella MeazzaDaniela Pende
Jun 6, 2009·European Journal of Immunology·Stephen O MathewPorunelloor A Mathew
Sep 11, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Loris ZamaiStefano Papa
Apr 3, 2003·Immunological Reviews·Sylvain Latour, André Veillette
Nov 17, 2009·Immunological Reviews·André VeilletteMario-Ernesto Cruz-Munoz

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