Early fish oil supplementation and organ failure in patients with septic shock from abdominal infections: a propensity-matched cohort study

JPEN. Journal of Parenteral and Enteral Nutrition
Christoph WohlmuthWalter R Hasibeder

Abstract

Fish oil (FO) has immunomodulating effects and may improve organ function and outcome in critically ill patients. This retrospective, propensity-matched cohort study investigates the effects of early intravenous FO supplementation on organ failure in patients with septic shock from abdominal infection. A medical database was retrospectively searched for critically ill patients admitted because of septic shock from abdominal infection (n = 194). Demographic, clinical, and laboratory data; FO supplementation (10 g/d) (n = 42); rate, degree, and number of organ failures assessed by the Sequential Organ Failure Assessment (SOFA) score; and secondary outcome variables were recorded. A propensity score-based model was used to establish 2 comparable groups (FO, n = 29; control, n = 29). Mann-Whitney rank sum test, Fisher exact test, and logistic regression analyses were used to compare variables between groups. There were no differences in the rate of single organ failures, the maximum SOFA score (median [interquartile range (IQR)], 12 [8-15] vs 11 [9-14]; P = .99), or the number of organ failures (median [IQR], 2 [1-3] vs 2 [1-3]; P = .54] between patients receiving FO supplementation and those not receiving supplementation. There we...Continue Reading

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Citations

Jan 29, 2013·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A Weimann
Mar 8, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Axel R HellerDaren K Heyland
Apr 10, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Richard D Fremont, Todd W Rice
Aug 10, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Osman AbbasogluAlessandro Pontes-Arruda
Jul 5, 2013·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Mark H DeLegge
Dec 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiuwen WuJianan Ren

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