Early formation of mRNP: license for export or quality control?

Molecular Cell
Torben Heick JensenMichael Rosbash

Abstract

Eukaryotic mRNA is processed by enzymes and packaged with proteins within nuclei to generate functional messenger ribonucleoprotein (mRNP) particles. Processing and packaging factors can interact with mRNA cotranscriptionally to form an early mRNP. Erroneous mRNP formation leads to nuclear retention and degradation of the mRNA. It therefore appears that one function of cotranscriptional mRNP assembly is to discard aberrant mRNPs early in their biogenesis. Cotranscriptional mRNP assembly may also enable the transcription machinery to respond to improper mRNP formation.

References

Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E D Lewis, J L Manley
Mar 1, 1994·The Journal of Cell Biology·A JarmolowskiI W Mattaj
Jul 1, 1995·Molecular and Cellular Biology·S Gunnery, M B Mathews
Apr 1, 1996·Molecular and Cellular Biology·Y Huang, G G Carmichael
Oct 17, 1998·Molecular and Cellular Biology·C E Brown, A B Sachs
May 18, 1999·The EMBO Journal·N CustódioM Antoniou
May 27, 1999·Genes & Development·Y HiroseJ L Manley
Jun 15, 1999·The Journal of Cell Biology·C JollyR I Morimoto
Jun 17, 1999·FEMS Microbiology Reviews·E Wahle, U Rüegsegger
Jul 27, 1999·Genes & Development·Y Wen, A J Shatkin
Sep 9, 2000·The Journal of Biological Chemistry·D P Morris, A L Greenleaf
Oct 6, 2000·Genes & Development·S C SchroederD Bentley
Oct 13, 2000·Cell·C Bousquet-AntonelliD Tollervey
Mar 30, 2001·The Journal of Biological Chemistry·Y L ChiuT M Rana

❮ Previous
Next ❯

Citations

Aug 11, 2004·The Journal of Biological Chemistry·Imke EhlersTilman Heise
Aug 3, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mingchao Ma, William M Strauss
Oct 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Carole GwizdekCatherine Dargemont
Oct 13, 2006·The Journal of Biological Chemistry·Susanne RötherKatja Strässer
Apr 6, 2007·The EMBO Journal·Mathieu RougemailleTorben Heick Jensen
Sep 6, 2007·Nature Reviews. Molecular Cell Biology·Alwin Köhler, Ed Hurt
Apr 26, 2008·FEBS Letters·Sérgio F de Almeida, Maria Carmo-Fonseca
Jun 20, 2008·Chromosoma·Manfred Schmid, Torben Heick Jensen
May 16, 2008·Biology of the Cell·Mathieu RougemailleDomenico Libri
Apr 3, 2004·Molecular and Cellular Biology·Christian Dimaano, Katharine S Ullman
May 11, 2004·Nature Structural & Molecular Biology·Jan RehwinkelElisa Izaurralde
Aug 18, 2004·Nature Cell Biology·Tamás FischerEd Hurt
Dec 16, 2005·Molecular and Cellular Biology·Karen AdelmanJohn T Lis
Jun 11, 2004·Annual Review of Biochemistry·Jeff Coller, Roy Parker
Apr 9, 2008·FEBS Letters·Nahid Iglesias, Françoise Stutz
Aug 12, 2010·Nucleic Acids Research·Sérgio F de AlmeidaMaria Carmo-Fonseca
Jul 3, 2007·EMBO Reports·Stepanka Vanacova, Richard Stefl
Dec 22, 2007·Nucleic Acids Research·Hiroyuki Fuke, Mutsuhito Ohno
Jun 4, 2005·Nature Structural & Molecular Biology·Milo B Fasken, Anita H Corbett
Oct 17, 2007·The Journal of Cell Biology·Noélia CustódioMaria Carmo-Fonseca
Apr 23, 2014·Nucleic Acids Research·Ichiro TaniguchiMutsuhito Ohno
Oct 16, 2004·Molecular and Cellular Biology·Joanna KufelDavid Tollervey
Aug 26, 2006·Reviews in Medical Virology·Othmar G Engelhardt, Ervin Fodor
Feb 26, 2004·Nature Structural & Molecular Biology·Elisa Izaurralde
Oct 29, 2010·Nature Communications·Anusha P DiasRobin Reed
Jun 1, 2010·Epigenomics·Sérgio F de Almeida, Maria Carmo-Fonseca
Jun 2, 2006·Molecular and Cellular Biology·Sonia JimenoAndrés Aguilera
May 18, 2004·Current Opinion in Cell Biology·Patrizia Vinciguerra, Françoise Stutz
May 26, 2004·Biochimica Et Biophysica Acta·Uwe Kühn, Elmar Wahle
May 20, 2004·Molecular Cell·Cherie L MuellerJudith A Jaehning
Sep 24, 2004·DNA Repair·Finn DrabløsHans E Krokan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biology of the Cell
Mathieu RougemailleDomenico Libri
Current Opinion in Cell Biology
Cyril SaguezTorben Heick Jensen
Current Opinion in Cell Biology
P Mitchell, David Tollervey
Molecular Cell
Torben Heick JensenDomenico Libri
© 2022 Meta ULC. All rights reserved