Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Robert D RoghairJeffrey L Segar

Abstract

Excessive exposure of the fetus to maternally derived corticosteroids has been linked to the development of adult-onset diseases. To determine if early gestation corticosteroid exposure alters subsequent coronary artery reactivity, we administered dexamethasone (0.28 mg.kg(-1).day(-1)) to pregnant ewes at 27-28 days gestation (term being 145 days). Vascular responsiveness was assessed in endothelium-intact coronary and mesenteric arteries isolated from steroid-exposed and age-matched control fetal sheep at 123-126 days gestation and lambs at 4 mo of age. Lambs exposed to maternal dexamethasone had higher mean arterial blood pressures than the age-matched controls (93 +/- 3 vs. 83 +/- 5 mmHg, P < 0.05). Mesenteric arteries from the steroid-exposed fetuses displayed diminished responses to ANG II, relative to controls. In 4-mo-old lambs, prenatal dexamethasone exposure significantly increased coronary artery vasoconstriction to ANG II, ACh, and U-46619, but not KCl. In contrast, postnatal mesenteric artery reactivity was unaltered by steroid exposure. Compared with fetal mesenteric reactivity, postnatal mesenteric reactivity to ANG II, phenylephrine, and U-46619 was diminished, whereas the response to 120 mmol/l KCl was heightene...Continue Reading

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Citations

Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert D RoghairFred S Lamb
Jul 27, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert D RoghairJeffrey L Segar
Mar 26, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth A VolkJeffrey L Segar
Nov 27, 2004·Biology of the Neonate·Peter D GluckmanCatherine S Pinal
Jun 29, 2010·Pediatric Research·Delrae M EckmanJorge P Figueroa
Feb 7, 2008·The Journal of Endocrinology·David O'ReganMegan C Holmes
Jan 1, 2008·Future Cardiology·Norma B OjedaBarbara T Alexander
Feb 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeong-Heon LeeJorge P Figueroa
Nov 24, 2007·The Journal of Pediatrics·Nancy ChorneRonald I Clyman
Jul 14, 2006·Kidney & Blood Pressure Research·Michiel SchreuderAns van Wijk
Jul 7, 2017·American Journal of Physiology. Renal Physiology·Anita J TurnerKaren J Gibson
May 14, 2016·World Journal of Clinical Pediatrics·Serafina PerroneGiuseppe Buonocore
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey Schwartz, Janna L Morrison
Mar 12, 2005·The Journal of Physiology·L DavisG D Giraud
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L SegarFred S Lamb
Aug 12, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Seth A ReiniMaureen Keller-Wood
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Nov 27, 2008·Clinical Science·Nicholas H von BergenThomas D Scholz
Jun 4, 2020·Journal of Developmental Origins of Health and Disease·Orlando A ValenzuelaEmilio A Herrera
Oct 27, 2006·Pediatric Research·Victor M Pulgar, Jorge P Figueroa

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