Abstract
Decision process about the acceptance of the deceased donor kidney for transplantation might be challenging. Although histological evaluation of pretransplant donor kidney biopsy provides reliable information regarding cortical necrosis, vascular thrombosis, extensive global glomerulosclerosis, and interstitial fibrosis/tubular atrophy, only electron microscopy enables thorough and reliable insights into microvasculature changes of kidney graft. The aim of the present paper is to briefly present two cases of early kidney graft loss. In one case, the donor was exposed to long-term extracorporeal membrane oxygenation (ECMO); in the other case, the donor experienced Takotsubo cardiomyopathy. In both cases, light microscopy of pretransplant biopsy found no pathology or significant discrepancy in morphology of kidney graft, while electron microscopy revealed severe endothelial dysfunction of renal microvasculature. Our results suggest that severe injury of renal microvasculature with relatively preserved tubular epithelium may be associated with some conditions of deceased kidney donors leading to early kidney graft nonfunction and loss. Further studies are needed to determine prognostic significance of severe ultrastructural microv...Continue Reading
References
Dec 1, 1982·Circulation·E Braunwald, R A Kloner
Sep 25, 1998·Cardiovascular Research·D J DunckerP D Verdouw
Feb 25, 1999·Transplantation·J PratschkeN L Tilney
Jul 4, 2003·American Journal of Nephrology·Norberto PericoGiuseppe Remuzzi
Feb 11, 2005·The New England Journal of Medicine·Ilan S WittsteinHunter C Champion
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jesse D ScholdHerwig-Ulf Meier-Kriesche
Mar 14, 2007·Circulation·John E DeanfieldTon J Rabelink
May 24, 2007·Basic Research in Cardiology·Solange C GarciaJochen D Schipke
Sep 20, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B MunivenkatappaB Philosophe
Nov 11, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Britt McILwainAkhil Maheshwari
Nov 23, 2010·Journal of the American College of Cardiology·Elizabeth A MartinAmir Lerman
May 18, 2011·Heart Failure Reviews·Athanasios Chalkias, Theodoros Xanthos
Jan 11, 2012·Nature Reviews. Nephrology·Winfred W WilliamsRobert B Colvin
Jan 26, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre GalichonEric Rondeau
May 9, 2014·Clinical Transplantation·Adam S BodzinNicholas C Cavarocchi
Jun 17, 2014·Clinical Transplantation·Benjamin PhilosopheRaghava B Munivenkatappa
Jan 10, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Nick J KoningChrista Boer
Jun 8, 2018·Frontiers in Immunology·Héloïse CardinalMarie-Josée Hébert
Citations
Nov 18, 2018·Transplantation·Henk P RoestLuc J W van der Laan
Dec 30, 2020·The Journal of International Medical Research·Andreja Aleš RiglerNika Kojc
Apr 28, 2021·Scientific Reports·H Tejeda-MoraM J Hoogduijn
Aug 7, 2021·Membranes·Gregorio MarchioriMarco Govoni