Early handling can attenuate adverse effects of fetal ethanol exposure

Alcohol
Joanne WeinbergW Yu

Abstract

The effects of early handling on physiological and hormonal responses of rats exposed to ethanol prenatally were studied. Male and female Sprague-Dawley rats from prenatal ethanol (E), pair-fed (PF), and ad lib-fed control (C) prenatal treatment groups were either handled (H) or nonhandled (NH) during the preweaning period and tested in adulthood. Early handling eliminated the deficit in preweaning weight gain observed in E compared to PF and C offspring. In adulthood, early handling eliminated the increased hypothermia observed in E and PF compared to C males following an ethanol challenge (2.0 g/kg, IP). In addition, H males displayed marginally less hypothermia overall than NH males. In contrast, handling accelerated the return to preinjection temperature in PF and C females but had no effect on E females. There were no significant differences among E, PF, and C rats in corticosterone (CORT) responses to ethanol challenge (1.5 g/kg, IP), but both males (marginally) and females in the H condition displayed higher CORT levels overall than NH rats. Early handling also eliminated the increased peak CORT response to restraint stress in E compared to C females, but did not affect the more prolonged elevation of CORT in E compared ...Continue Reading

References

Mar 29, 1979·Psychopharmacology·E P RileyN R Shapiro
Nov 1, 1979·American Heart Journal·C N Steeg, P Woolf
Jul 1, 1977·Alcoholism, Clinical and Experimental Research·C L RandallD W Walker
Feb 1, 1979·Pharmacology, Biochemistry, and Behavior·E P RileyJ Baldwin
Nov 1, 1979·Pharmacology, Biochemistry, and Behavior·E P RileyE A Lochry
Jun 1, 1977·Teratology·G F Chernoff
May 1, 1978·Physiology & Behavior·J WeinbergS Levine
May 1, 1978·Developmental Psychobiology·J WeinbergS Levine
Mar 1, 1977·Developmental Psychobiology·J Weinberg, S Levine
Jul 1, 1991·Neurotoxicology and Teratology·R T BrownA Falek
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·J Weinberg, T D Petersen
Aug 1, 1990·Physiology & Behavior·A Wakshlak, M Weinstock
May 1, 1986·Journal of Steroid Biochemistry·S M EmadianC L Densmore
Feb 1, 1989·Alcoholism, Clinical and Experimental Research·J Weinberg
Aug 1, 1989·Alcoholism, Clinical and Experimental Research·P Angelogianni, C Gianoulakis
Nov 24, 1987·European Journal of Pharmacology·S R BodnoffM J Meaney
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·L R NelsonB J Branch
Oct 1, 1988·Alcoholism, Clinical and Experimental Research·J Weinberg
Jun 1, 1987·Alcoholism, Clinical and Experimental Research·J Weinberg, S Bezio
Jan 1, 1985·Alcoholism, Clinical and Experimental Research·J Weinberg
Nov 3, 1973·Lancet·K L Jones, D W Smith
Aug 1, 1973·British Journal of Psychology·M Daly
Jul 1, 1981·Endocrinology·M KanekoM F Dallman
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·A N TaylorN Kokka
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·A N TaylorN Kokka
Jun 1, 1981·Pediatric Research·S JohnsonR W Steele
Jun 1, 1982·Journal of Developmental and Behavioral Pediatrics : JDBP·H C SteinhausenH L Spohr
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·N AnandamJ M Stern
Oct 29, 1993·Annals of the New York Academy of Sciences·M J MeaneyP M Plotsky
Jul 1, 1993·Neurotoxicology and Teratology·J H HanniganC S Zajac
Feb 1, 1996·Alcoholism, Clinical and Experimental Research·J WeinbergC Gianoulakis
May 1, 1960·Scientific American·S LEVINE

❮ Previous
Next ❯

Citations

Jul 13, 2002·Developmental Psychobiology·Kara I GabrielJoanne Weinberg
Jun 22, 2002·Pharmacology, Biochemistry, and Behavior·Betty Zimmerberg, Heather E Weston
Mar 11, 1999·Archives of Medical Research·S Brailowsky, O García
May 12, 2001·Neurotoxicology and Teratology·K I Gabriel, J Weinberg
Jan 21, 2000·Neurotoxicology and Teratology·P ClausingB Opitz
Jan 21, 2000·Neurotoxicology and Teratology·A Y KlintsovaW T Greenough
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·C K KimJ Weinberg
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·K I GabrielJ Weinberg
Jun 19, 2001·Alcoholism, Clinical and Experimental Research·K I GabrielJ Weinberg
Oct 5, 2001·Alcoholism, Clinical and Experimental Research·M L SchneiderG W Kraemer
Mar 10, 2007·Genetic, Social, and General Psychology Monographs·Matthew J HertensteinRachel M Holmes
Jun 25, 2005·Alcoholism, Clinical and Experimental Research·Norman E Spear, Juan C Molina
Nov 23, 2006·Alcoholism, Clinical and Experimental Research·David W HaleyJean Lowe
Sep 5, 2009·Developmental Disabilities Research Reviews·Sandra J KellyJohn H Hannigan
Mar 16, 2013·Alcoholism, Clinical and Experimental Research·Ni LanJoanne Weinberg
Aug 17, 2006·Neuroscience and Biobehavioral Reviews·John H HanniganRobert F Berman
Mar 30, 2006·Behavioural Brain Research·John L BeardMichael K Georgieff
Apr 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthew O ParkerCaroline H Brennan
Aug 19, 2014·Developmental Psychobiology·Charlis RainekiJoanne Weinberg
Jan 21, 2015·Physiology & Behavior·John H HanniganVirginia Delaney-Black

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.