Early healing rates and wound area measurements are reliable predictors of later complete wound closure

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Matthew CardinalKeith Harding

Abstract

This study was undertaken to determine if healing rates are reliable early predictors of ultimate complete wound closure in venous leg ulcers and diabetic foot wounds. We conducted a retrospective analysis of 306 venous leg ulcers and 241 diabetic foot ulcers enrolled in two large controlled, prospective, randomized pivotal trials to compare topical wound treatments, to determine whether certain early markers of healing could be correlated with later total wound closure. Two-sided tests at 95% confidence demonstrated that wound margin advance, initial healing rate, percent wound surface area reduction, and wound healing trajectories (all p<0.001) were powerful predictors of complete wound healing at 12 weeks. Wounds with poor healing progress by these criteria at 4 weeks were highly likely to remain unhealed after 8 additional weeks of treatment. Analysis of the diabetic foot ulcers and venous leg ulcers subgroups separately demonstrated consistent statistical test results with high significance; similarly, the results remained valid independent of the topical treatment used. The early prediction of eventual wound healing or nonhealing using early healing rates may enable more efficient triage of patients to advanced healing te...Continue Reading

References

Mar 1, 1993·Journal of the American Academy of Dermatology·D J MargolisG S Lazarus
Mar 1, 1996·Journal of Vascular Surgery·D R GorinJ O Manzoian
Oct 24, 1997·Archives of Dermatology·P TallmanV Falanga
Jan 6, 1999·Archives of Dermatology·J Kantor, D J Margolis
Jul 15, 2000·Archives of Surgery·M C RobsonD L Steed
Dec 18, 2002·The Journal of Investigative Dermatology·Joel M GelfandDavid J Margolis
May 27, 2003·Diabetes Care·David J MargolisJesse A Berlin
Apr 17, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·David J MargolisJesse A Berlin
Jun 30, 2004·American Journal of Surgery·D P HillGeorge W Cherry
Jun 30, 2004·American Journal of Surgery·Sylvan Wallenstein, Harold Brem
May 4, 2005·The International Journal of Lower Extremity Wounds·Thomas Gilman
May 3, 2006·International Wound Journal·David L SteedMartin C Robson

❮ Previous
Next ❯

Citations

May 17, 2011·Diabetes Technology & Therapeutics·Piotr FoltynskiJan Wojcicki
Aug 2, 2013·Diabetes Technology & Therapeutics·Piotr FoltynskiJan M Wojcicki
Apr 13, 2011·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Catherine E Hammond, Mark A Nixon
Apr 2, 2009·BMC Dermatology·Matthew CardinalDavid G Armstrong
Apr 25, 2014·Advances in Wound Care·Gerard Koel, Pamela E Houghton
Jan 29, 2014·Journal of Foot and Ankle Research·Peter A LazzariniLloyd F Reed
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky Infectious Diseases Society of America
Aug 21, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Liza BraunLawrence A Lavery
Jul 22, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alvar GrönbergOla Rollman
Jan 24, 2012·Scandinavian Cardiovascular Journal : SCJ·Rami P LaitioTimo J A Savunen
Mar 13, 2014·International Wound Journal·Matthias AugustinReinhard Rychlik
May 4, 2010·Archives of Physical Medicine and Rehabilitation·Pamela E HoughtonM Gail Woodbury
Jun 23, 2009·International Wound Journal·David G ArmstrongDavid J Margolis
Aug 8, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shanu K KurdDavid J Margolis
Aug 8, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Matthew CardinalKeith Harding
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Corinna WickeAlfred Königsrainer
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jouko Viljanto, Antti Koski
Jun 12, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Sylvie MeaumeUNKNOWN CHALLENGE Study Group
Jul 28, 2010·International Wound Journal·Elia B RicciCristiana Di Campli
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Maria J C MachadoChristopher A Mitchell
Aug 6, 2013·The British Journal of Dermatology·G ChabyUNKNOWN Angio-Dermatology Group of the French Society of Dermatology
Feb 21, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Julia C ArcieroDavid Swigon
Jul 25, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nick SantamariaAlexandra Gorelik
Jul 4, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shinji IizakaUNKNOWN Scientific Education Committee of the Japanese Society of Pressure Ulcers
Jul 19, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jennifer C TangRobert S Kirsner
Jan 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jaymie PanuncialmanVincent Falanga
Nov 26, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kenneth JungNigam H Shah
Sep 5, 2015·Advances in Wound Care·Robert G Frykberg, Jaminelli Banks
Jul 5, 2016·Archives of Physical Medicine and Rehabilitation·Marylou GuihanBarbara M Bates-Jensen
Sep 25, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Alicja KrejnerTomasz Grzela
Nov 20, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xin QiJue Zhang
Nov 18, 2016·The International Journal of Lower Extremity Wounds·Jonathan SmedleyYeabsera G Tamire
Aug 25, 2017·The International Journal of Lower Extremity Wounds·Anne PurcellAndrea P Marshall
Dec 19, 2017·The International Journal of Lower Extremity Wounds·Javier Aragón-SánchezMaría José Hernández-Herero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Nada Kecelj LeskovecTomaz Lunder
American Journal of Surgery
Sylvan Wallenstein, Harold Brem
© 2021 Meta ULC. All rights reserved