Early hemodynamic changes in experimental intracerebral hemorrhage

Journal of Neurosurgery
F P NathG M Teasdale

Abstract

A model of experimental intracerebral hemorrhage is described in which carefully controlled volumes of autologous blood were injected at arterial pressure into the caudate nucleus of the rat. A comparison of intracranial pressure changes and local cerebral blood flow (CBF) was made between three groups of rats, each receiving different injection volumes, and sham-operated control rats by monitoring intraventricular pressure and by obtaining quantitative autoradiographic measurements of CBF within 1 minute of the experimental hemorrhage. Cerebral blood flow was reduced both around the hematoma and in the surrounding brain. This change was strongly volume-dependent and was not accompanied by significant alterations in cerebral perfusion pressure. This finding suggests that the degree of ischemia at the time of an intracerebral bleed depends on the size of the lesion, and implicates local squeezing of the microcirculation by the hematoma, rather than a generalized alteration in perfusion pressure, as the cause of ischemia.

References

Mar 1, 1978·The American Journal of Physiology·T J HougenT W Smith
Jul 1, 1979·Archives of Neurology·L A Weisberg
Jan 1, 1983·Acta neurochirurgica·F P NathR J Fraser
Mar 1, 1982·Annals of Neurology·A H Ropper, N T Zervas
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Nov 1, 1964·Journal of Neurosurgery·T W LANGFITTL J GAGLIARDI

❮ Previous
Next ❯

Citations

Jan 1, 1990·Acta neurochirurgica·J M González-Darder, J Durán-Cabral
Dec 7, 2007·Neurocritical Care·Michael Lucas JamesDaniel T Laskowitz
Mar 8, 2000·Journal of the Neurological Sciences·E Lopez ValdesC Gomez-Escalonilla
Mar 18, 2004·Neuroimaging Clinics of North America·William J Powers, Allyson R Zazulia
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Jan 20, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C-H WuL-D Chen
Nov 1, 1987·Journal of Neurosurgery·T A KingmanG M Teasdale
Feb 1, 1990·Journal of Neurosurgery·J P BroderickJ Spilker
Feb 25, 2005·Neurological Research·Masataka Takahashi, R Loch Macdonald
Jul 1, 2012·Translational Stroke Research·Daniel BodmerE Sander Connolly
Jan 1, 1988·Acta neurochirurgica·J M GilsbachM E Hornyak
Jun 15, 2010·PET Clinics·William J Powers, Allyson R Zazulia
Feb 7, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zhen YuChang-Lin Hu
Aug 4, 2007·Mayo Clinic Proceedings·Kristine M ThompsonJulia A Files
Jun 7, 2007·Journal of the Neurological Sciences·Qaisar A ShahAdnan I Qureshi
Jul 14, 2005·Journal of Neurochemistry·Jiping TangJohn H Zhang
Sep 1, 1989·Neuropathology and Applied Neurobiology·A JenkinsD I Graham
Sep 6, 2005·Free Radical Biology & Medicine·Antonio CherubiniPatrizia Mecocci
Jan 1, 1997·Critical Care Clinics·R E Adams, W J Powers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.