PMID: 6539291May 1, 1984Paper

Early hepatic histologic alterations among chemical (vinyl monomer) workers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
C H TamburroH Popper

Abstract

Focal hepatocellular hyperplasia and focal mixed (hepatocytes and sinusoidal cells) hyperplasia are early histological alterations indicative of vinyl monomer exposure. To evaluate their uses in screening chemical workers, 93 liver biopsy specimens from 78 persons were examined in double-blind duplicative fashion. Forty-eight specimens were from exposed chemical workers, 35 of them having liver biopsy(ies) for hepatic test abnormalities and 13 for nonliver -related reasons. A comparison group consisted of 30 nonchemical workers who had undergone liver biopsy for nonliver related reasons. Twenty-three of the exposed workers (48%) had hepatic lesions consistent with exposure: 17 (35%) of these had focal hepatocytic hyperplasia, while 6 (13%) had focal mixed hyperplasia or more advanced lesions. Only five of the comparison group had like findings: four (13%) had focal hepatocytic hyperplasia; one had focal mixed hyperplasia and sinusoidal dilatation. This individual had persistent hepatic test abnormalities with the focal mixed hyperplasia and a sinusoidal dilatation, and on subsequent biopsy, angiosarcoma (and a history of using hair spray containing vinyl chloride propellant ). Ten individuals had 25 multiple biopsies also read ...Continue Reading

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Citations

Aug 23, 1986·Lancet·S Sherlock
Dec 25, 2002·Occupational and Environmental Medicine·M MaroniA C Fanetti
Jun 1, 1994·Pathology, Research and Practice·H W Altmann
Mar 6, 2003·Human Mutation·Frank StaibCurtis C Harris
Nov 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Matt CaveCraig J McClain
Jan 1, 1989·Journal of Hepatology·E S Zafrani
Jan 1, 1985·The American Journal of Medicine·G M LissC H Tamburro
Oct 20, 2009·Journal of Hepatology·Morris Sherman
Dec 25, 2012·Toxicologic Pathology·Banrida WahlangMatt C Cave
Mar 7, 2018·Hepatology Communications·Anna L LangJuliane I Beier
Nov 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Banrida WahlangJuliane I Beier
May 5, 2018·Chemical Research in Toxicology·Yaqin LiangLu Cai

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