Early hepatocellular carcinoma with high-grade atypia in small vaguely nodular lesions

Cancer Science
Hidenori OjimaMichiie Sakamoto

Abstract

Multistep hepatocarcinogenesis progresses from dysplastic nodules to early hepatocellular carcinoma (eHCC) and to advanced HCC. The aim of the present study was to investigate the detailed histopathological features of eHCC. We investigated 66 small vaguely nodular lesions resected from 40 patients. The degree of cellular and structural atypia and stromal invasion were assessed. The immunohistochemical expression of HCC-related markers adenylate cyclase-associated protein 2 (CAP2), heat shock protein 70 (HSP70), Bmi-1, CD34 and h-caldesmon were evaluated. Of the 66 nodules, 10 were diagnosed as low-grade dysplastic nodules (LGDN), 10 as high-grade dysplastic nodules (HGDN) and 46 as eHCC. Among the 46 eHCC, 18 nodules (39.1%) showed marked stromal invasion and/or the presence of the scirrhous component and were subclassified as high-grade eHCC (HGeHCC). The remaining 28 eHCC, which lacked these features, were subclassified as low-grade eHCC (LGeHCC) and were examined further. HGeHCC showed high levels of cellular and structural atypia and large tumor size. The immunohistochemical expression of CAP2 and the area of sinusoidal vascularization showed increases from LGDN to HGeHCC. The density of arterial tumor vessels was high in ...Continue Reading

References

Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Makoto ChumaSetsuo Hirohashi
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rie ShibataMichiie Sakamoto
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca Di TommasoMassimo Roncalli
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Michiie Sakamoto
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN International Consensus Group for Hepatocellular NeoplasiaThe International Consensus Group for Hepatocellular Neoplasia
Jul 7, 2010·Japanese Journal of Clinical Oncology·Michiie SakamotoYohei Masugi
May 25, 2011·Journal of Magnetic Resonance Imaging : JMRI·Utaroh MotosugiTsutomu Araki
Jun 28, 2011·AJR. American Journal of Roentgenology·Takashi KumadaTeruyoshi Ishikawa

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