Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade

Shock
Rui YanGrietje Molema

Abstract

Hemorrhagic shock (HS) is associated with low blood pressure due to excessive loss of circulating blood and causes both macrocirculatory and microcirculatory dysfunction. Fluid resuscitation after HS is used in the clinic to restore tissue perfusion. The persistent microcirculatory damage caused by HS and/or resuscitation can result in multiple organ damage, with the kidney being one of the involved organs. The kidney microvasculature consists of different segments that possess a remarkable heterogeneity in functional properties. The aim of this study was to investigate the inflammatory responses of these different renal microvascular segments, i.e., arterioles, glomeruli, and postcapillary venules, to HS and resuscitation (HS/R) in mice and to explore the effects of intervention with a nuclear factor-kappa B (NF-κB) inhibitor on these responses. We found that HS/R disturbed the balance of the angiopoietin-Tie2 ligand-receptor system, especially in the glomeruli. Furthermore, endothelial adhesion molecules, proinflammatory cytokines, and chemokines were markedly upregulated by HS/R, with the strongest responses occurring in the glomerular and postcapillary venous segments. Blockade of NF-κB signaling during the resuscitation pe...Continue Reading

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Citations

Jan 15, 2019·Shock·Lyle L Moldawer
Mar 16, 2021·American Journal of Physiology. Renal Physiology·Rosa G M LammertsStefan P Berger
Mar 19, 2021·Frontiers in Immunology·Pierre-Olivier LudesAlexandre Mebazaa
May 18, 2021·Intensive Care Medicine Experimental·Anoek L I van LeeuwenCharissa E van den Brom

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Methods Mentioned

BETA
nuclear translocation
Laser microdissection
electrophoresis
PCR
FCS
transgenic

Software Mentioned

GraphPad Prism
Leica
ImageScope

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