PMID: 22552456May 4, 2012Paper

Early HHV-6 replication is associated with morbidity non-related to CMV infection after kidney transplantation

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Regina Barbosa SchroederElizete Keitel

Abstract

Human herpesvirus type 6-(HHV-6) has been associated with morbidity after liver transplantation. The aim of this study was to determine the HHV-6 seroprevalence among donor-recipient pairs, analyze the incidence of early active infection, its clinical manifestation, interaction with CMV, and the related morbidity in the first year after kidney transplantation. 46 donor-recipient pairs had IgG evaluated by ELISA before transplantation: HHV-6(Pambio - USA) and CMV-(Roche - USA). A frozen whole blood sample collected weekly (from the 1st to the 6th week) was retrospectively tested for HHV-6 viral load (VL) determination by real time quantitative PCR (qPCR, Nanogen - Italy). Patients were preemptively surveyed for CMV by pp65 antigenemia (Ag, APAAP, immunohistochemistry, Biotest - Germany) from the 4th to the 12th week after transplantation. Active infection was defined as qPCR-HHV6+ (viral-load/mL-VL) and Ag+ (+cells/100.000 granulocytes), for HHV-6 and CMV, respectively. DCMV was defined as simultaneous positive antigenemia and suggestive signs/symptoms. Concerning +qPCR-HHV6, associated factors, clinical manifestation, interaction with CMV and morbidity were searched. Pre-transplant HHV-6 seroprevalence was significantly higher ...Continue Reading

References

Jun 1, 1996·Antiviral Research·P Lusso
Jul 26, 2000·Transplantation·I LautenschlagerK Höckerstedt
Jan 18, 2005·Clinical Microbiology Reviews·Leen De BolleErik De Clercq
Feb 25, 2005·The New England Journal of Medicine·Danielle M ZerrLawrence Corey
Jun 29, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sushruth Reddy, Pradip Manna
Jan 13, 2006·European Neurology·A M VisserM J van den Bent
Jan 19, 2006·Clinical Microbiology Reviews·M J EspyT F Smith
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·R N GunsonW F Carman
Mar 11, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiansheng Chen, S David Hudnall
Dec 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Masahiro OhashiTetsushi Yoshikawa

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Citations

Aug 30, 2019·Journal of Medical Virology·Flavia Savassi-RibasRafael Brandão Varella

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