Early histopathologic changes in purple glove syndrome

Journal of Cutaneous Pathology
Pradip Bhattacharjee, Earl J Glusac

Abstract

An 86-year-old African-American man presented with tonic-clonic seizures. Intravenous phenytoin was urgently administered into the dorsum of the right hand. The patient developed a raised purple area of discoloration around the intravenous insertion site within 2 h and edema and vesiculobullous lesions of the distal forearm, hands, and fingers within 8 h. Microscopic sections from a biopsy at 12 h revealed epidermal necrosis, superficial ulceration, and a mild superficial and deep perivascular lymphoid infiltrate, associated with numerous thrombi of small vessels throughout the dermis. The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome. Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands. It is comprised by pain, discoloration, and edema in the vicinity of intravenous infusion of phenytoin through dorsal veins of the hand. The histopathologic features of fully developed lesions have been reported; however, early-stage findings have not been pr...Continue Reading

References

Dec 1, 1992·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·D R Hanna
Nov 1, 1988·The Journal of Hand Surgery·H J Hagan, H Hastings
Nov 1, 1984·The New England Journal of Medicine·H S Silverman
Oct 1, 1983·Drug Intelligence & Clinical Pharmacy·M E MacCara
Nov 1, 1994·Acta Paediatrica·N Sharief, C Goonasekera
Jan 1, 1994·Journal of Neurosurgical Anesthesiology·M A Helfaer, C Ware
Feb 1, 1993·Journal of the American Academy of Dermatology·A G Hayes, T M Chesney
Aug 1, 1995·The American Journal of Dermatopathology·S J Hunt
Jan 31, 2002·The Annals of Pharmacotherapy·Sandra M ten HolderRonald J Falk

❮ Previous
Next ❯

Citations

Mar 9, 2010·Journal of Medical Case Reports·Georgene SinghBinu P Thomas
Jan 15, 2014·Pharmacotherapy·Paul M ReynoldsTyree H Kiser
Jul 3, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Lyudmila A GarbovskyJeanmarie Perrone
Sep 26, 2015·Hospital Pharmacy·John I OkogbaaRebecca A Lillis
Jul 30, 2014·The American Journal of Emergency Medicine·Rajendra Singh JainRahul Handa
Apr 25, 2007·Vascular Medicine·Reena ChokshiEmile Mohler
Nov 3, 2007·European Journal of Anaesthesiology·R P MahajanS Rajeev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.