Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response

The Journal of Infectious Diseases
P J CooperT B Nutman

Abstract

The immune response after early exposure to or infection with Onchocerca volvulus was investigated in an autochthonous focus caused by the migration of infected persons to a previously unaffected area in Ecuador. Peripheral blood mononuclear cell (PBMC) proliferative and cytokine responses (interferon [IFN]-gamma and interleukin [IL]-5) to filarial antigens were measured in 14 subjects with serologic evidence of exposure and in 7 subjects with evidence of dermal microfilarial DNA and were compared with responses in 43 subjects with chronic O. volvulus infections. PBMC proliferative and cytokine responses (IFN-gamma and IL-5) to parasite antigens were elevated in the early exposure/infection group, compared with those in the chronic infection group. Addition of an IL-10-neutralizing antibody to filaria antigen-stimulated cultures resulted in significantly elevated proliferative responses in the chronic infection group. The findings suggest that early exposure and early parasite patency are associated with a vigorous cellular response, but, as infections become chronic, the cellular response becomes down-regulated, partly through an IL-10-dependent mechanism.

Citations

Sep 3, 2002·International Journal for Parasitology·Laetitia Le GoffJudith E Allen
Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·P J CooperG E Griffin
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Don N Udall
Nov 22, 2005·Infection and Immunity·Laura A KerepesiDavid Abraham
Mar 6, 2012·PLoS Neglected Tropical Diseases·Cathy SteelThomas B Nutman
Mar 22, 2013·PLoS Pathogens·Nienke van der WerfMatthew D Taylor
May 8, 2009·Folia Histochemica Et Cytobiologica·Joanna Matowicka-KarnaHalina Kemona
Sep 24, 2005·Parasite Immunology·A HoeraufS Specht
Sep 14, 2004·Immunological Reviews·Rick M MaizelsJudith E Allen
Jan 7, 2004·Cellular Microbiology·A G HiseE Pearlman
Sep 13, 2006·Parasite Immunology·S M Kamal, K El Sayed Khalifa
Jan 31, 2015·PLoS Pathogens·Soumya Chatterjee, Thomas B Nutman
Sep 2, 2003·Nature Reviews. Immunology·Rick M Maizels, Maria Yazdanbakhsh
May 1, 2009·Mucosal Immunology·P J Cooper
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·David LarsonEdward Mitre
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cathy Steel, Thomas B Nutman
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subash Babu, Thomas B Nutman
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D TaylorRick M Maizels
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D TaylorJudith E Allen
Apr 25, 2018·Parasites & Vectors·Ángel GuevaraRonald H Guderian

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