Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

The British Journal of Ophthalmology
Sean T GarrityDavid Sarraf

Abstract

Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing. Data from patients with chronic HCQ exposure was obtained from seven tertiary care retina centres. Ten patients with HCQ-associated OCT abnormalities and normal HVF testing were identified. Detailed analysis of the OCT findings and ancillary tests including colour fundus photography, fundus autofluorescence, multifocal electroretinography and microperimetry was performed in these patients. Seventeen eyes from 10 patients illustrated abnormalities with OCT and normal HVF testing. These OCT alterations included (1) attenuation of the parafoveal ellipsoid zone and (2) loss of a clear continuous interdigitation zone. Several eyes progressed to advanced parafoveal outer retinal disruption and/or paracentral visual field defects. Patients with high risk HCQ exposure and normal HVF testing may develop subtle but characteristic OCT abnormalities. This novel finding indicates that...Continue Reading

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Citations

Sep 26, 2020·Investigative Ophthalmology & Visual Science·Vivienne C GreensteinJanet R Sparrow
Sep 17, 2020·Translational Vision Science & Technology·Clara ReichelThomas Ach
Sep 4, 2020·Vestnik oftalmologii·M V Budzinskaya, M H Durzhinskaya
Nov 20, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Ulrich KellnerGhazaleh Farmand
Sep 29, 2021·Investigative Ophthalmology & Visual Science·Enrico BorrelliGiuseppe Querques
Jan 12, 2022·Investigative Ophthalmology & Visual Science·Gopal JayakarCatherine A Cukras
Jan 28, 2022·European Journal of Ophthalmology·Lidia Remolí SarguesEnrique Cervera Taulet

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