PMID: 8606475Feb 21, 1996Paper

Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants

JAMA : the Journal of the American Medical Association
A VarvarigouJ V Aranda

Abstract

To test whether early postnatal (0 to 3 hours) intravenous administration of ibuprofen will prevent patent ductus arteriosus (PDA) in preterm neonates. Prospective sequential controlled trial with three treatment arms. Level 3 perinatal-neonatal intensive care nursery. Thirty-four premature newborn infants born from February to August 1993 with a mean birth weight of 913 g (range, 565 to 1460 g) and gestational age of 26.9 weeks (range, 22.4 to 31.0). Infants were consecutively assigned within 3 hours of age to treatment with either one dose of ibuprofen lysine (10 mg/kg intravenously) followed by 5 mg/kg per dose intravenously at 24 and 48 hours of age (n = 12), one dose of ibuprofen lysine (10 mg/kg intravenously; n = 11), or saline (n = 11). Primary outcome variable was the presence of ductus arteriosus by echocardiography and clinical assessments at 3, 7, and 21 days of life. Secondary outcome variables included presence of intraventricular hemorrhage, renal function, ventilatory and oxygen needs, hematologic changes, gastrointestinal function, time to full enteral feeding, duration of hospitalization, and age at discharge. The three groups of patients were comparable in birth weight, gestational age, antenatal administrati...Continue Reading

Citations

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