Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study.

Critical Care : the Official Journal of the Critical Care Forum
P PóvoaH Sabino

Abstract

Manifestations of sepsis are sensitive but are poorly specific of infection. Our aim was to assess the value of daily measurements of C-reactive protein (CRP), temperature and white cell count (WCC) in the early identification of intensive care unit (ICU)-acquired infections. We undertook a prospective observational cohort study (14 month). All patients admitted for > or =72 hours (n = 181) were divided into an infected (n = 35) and a noninfected group (n = 28). Infected patients had a documented ICU-acquired infection and were not receiving antibiotics for at least 5 days before diagnosis. Noninfected patients never received antibiotics and were discharged alive. The progression of CRP, temperature and WCC from day -5 to day 0 (day of infection diagnosis or of ICU discharge) was analyzed. Patients were divided into four patterns of CRP course according to a cutoff value for infection diagnosis of 8.7 mg/dl: pattern A, day 0 CRP >8.7 mg/dl and, in the previous days, at least once below the cutoff; pattern B, CRP always >8.7 mg/dl; pattern C, day 0 CRP < or =8.7 mg/dl and, in the previous days, at least once above the cutoff; and pattern D, CRP always < or =8.7 mg/dl. CRP and the temperature time-course showed a significant incr...Continue Reading

References

Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Jun 3, 1988·Science·J A Swets
Apr 1, 1987·Archives of Internal Medicine·J W MellorsS M Horwitz
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jul 1, 1995·Intensive Care Medicine·S M YentisJ Sheldon
Jan 11, 1995·JAMA : the Journal of the American Medical Association·M S Rangel-FraustoR P Wenzel
Apr 1, 1994·The Annals of Thoracic Surgery·P IcardP Levasseur
Apr 1, 1993·The Journal of Clinical Investigation·D M VigushinP N Hawkins
Feb 1, 1997·Critical Care Medicine·J L Vincent
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Apr 13, 1999·Critical Care Medicine·H UgarteJ L Vincent
Jul 17, 1999·Immunopharmacology·C MoldT W Du Clos
Sep 2, 1999·Intensive Care Medicine·B CirciumaruJ Cohen
May 17, 2002·Current Opinion in Infectious Diseases·Lisa A Greisman, Philip A Mackowiak
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Jun 10, 2003·Critical Care Medicine·Aldo LuzzaniAlberto Merlini
Feb 1, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P PóvoaH Sabino
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hester VermeulenDink A Legemate
May 3, 2005·The European Respiratory Journal·P PóvoaH Sabino

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Citations

May 21, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pedro PóvoaJorgeI F Salluh
Jul 19, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pedro PóvoaUNKNOWN Portuguese Community-Acquired Sepsis Study Group SACiUCI
Jun 30, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michal KyrJaroslav Michalek
Mar 17, 2010·Critical Care : the Official Journal of the Critical Care Forum·Ayman Abd Al-Maksoud YousefGhada Abdulmomen Suliman
Nov 29, 2013·BioMed Research International·Christophe LelubreMichaël Piagnerelli
Apr 12, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T MölkänenA Järvinen
Apr 15, 2016·Annals of Intensive Care·Pedro PóvoaAntonio Artigas
Dec 22, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M ParkL M Cruz-Neto
Oct 29, 2008·Clinics in Chest Medicine·Corey E Ventetuolo, Mitchell M Levy
May 16, 2014·The Journal of International Medical Research·Hong-Xiang LiYu-Shan Wang
Dec 21, 2017·BMC Pregnancy and Childbirth·Seng ChuaHayley Diplock
Nov 29, 2014·BMC Infectious Diseases·Almudena Burillo, Emilio Bouza
Mar 5, 2008·Current Opinion in Infectious Diseases·Pedro Póvoa
Jun 17, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T MölkänenA Järvinen
May 19, 2009·Clinical Oral Investigations·Lotta SeppänenAnneli Lauhio
Sep 19, 2012·Critical Care Medicine·Andre Miguel Japiassu, Fernando A Bozza
Aug 2, 2017·Current Opinion in Critical Care·Jorge I F SalluhPedro Póvoa
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Luis E Huerta, Todd W Rice
Dec 15, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Dan LiuLi-Xin Xie
Mar 29, 2014·Experimental and Therapeutic Medicine·Mingyi ChenLei He
Dec 27, 2018·Current Opinion in Pulmonary Medicine·Filipe FroesPedro Póvoa
Jun 4, 2015·Critical Care Nursing Quarterly·Reba UmbergerMary Lynn Brown
Apr 30, 2009·Anaesthesia and Intensive Care·K M Ho, J Lipman
May 1, 2017·Korean Journal of Critical Care Medicine·Kyung Soo ChungMoo Suk Park
Mar 6, 2013·Expert Review of Anti-infective Therapy·Jean-Louis Vincent, Marjorie Beumier
Apr 27, 2019·International Journal of Molecular Sciences·Meropi Karakioulaki, Daiana Stolz
Feb 13, 2021·Journal of Clinical Medicine·Jarno F KronbergerDawid L Staudacher
Feb 18, 2016·Journal of Critical Care·David M GriffithTimothy S Walsh
Feb 23, 2021·Current Infectious Disease Reports·Aaron J Heffernan, Kerina J Denny
Mar 13, 2021·Journal of Biomedical Informatics·Maya SchvetzRobert Moskovitch
Sep 21, 2021·Seminars in Respiratory and Critical Care Medicine·Pedro Póvoa, Luis Coelho
Dec 16, 2009·International Journal of Antimicrobial Agents·Ephraim L Tsalik, Christopher W Woods
Mar 29, 2011·Critical Care Clinics·Jean-Louis VincentXavier Schmit

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