Early identification of leptospirosis as an ignored cause of multiple organ dysfunction syndrome

Shock
Huang-Yu YangChih-Wei Yang

Abstract

Leptospirosis is the most common zoonosis in the world but remains underreported, owing to protean manifestations and ignorance about the disease among health care providers in Taiwan. From September 2000 to March 2006, surveillance of 455 patients with multiple organ dysfunction syndrome with unclear cause or clinical suspicion of leptospirosis was performed. Diagnosis was further confirmed by microscopic agglutination test or isolation of Leptospira. Cases were classified as excluded based on confirmed etiology other than leptospirosis or negative paired serologic test. Forty-two patients were confirmed as having leptospirosis, which accounted for 9.2% of total patients with multiple organ dysfunction syndrome. Forty-nine excluded cases were identified for a case-control analysis for clinical distinction. The most common presentations of leptospirosis were fever (97.6%), acute kidney injury (85.7%), and jaundice (61.9%). The leptospirosis group showed lower urine specific gravity (cutoff value, 1.0145) and enlarged kidney size (cutoff value, 11.05 cm) as compared with the excluded cases by multivariate logistics regression. Delayed antibiotic administration prolongs the duration of hospitalization (R2 = 0.486, P < 0.01). No m...Continue Reading

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Citations

Aug 21, 2014·International Journal of Environmental Research and Public Health·Wilawan ThipmontreeSaowaluk Silpasakorn
Oct 1, 2016·International Journal of Molecular Sciences·Haorile Chagan-YasutanToshio Hattori
Dec 1, 2020·PloS One·Elise Klement-FrutosCyrille Goarant

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