Early identification of renal transplant recipients with high risk of polyomavirus-associated nephropathy

Medical Microbiology and Immunology
K TeutschV Di Cristanziano

Abstract

Polyomavirus BK (BKPyV) is ubiquitous among humans. Following primary infection, the virus remains latent predominantly in the hosts' uroepithelial cells. Up to 10 % of renal transplant recipients show a viral reactivation that can lead to polyomavirus-associated nephropathy (PyVAN). In the absence of early treatments, the risk of graft loss is up to 80 %. Monitoring viral load in urine and plasma by real-time PCR after transplantation is the most common diagnostic tool to detect viral reactivation. In the present retrospective study, BKPyV-DNA loads in urine and plasma by quantitative real-time PCR were associated with clinical data, including HLA haplotype, blood parameters and viral genotype, of 40 renal transplant recipients at the University Clinics of Cologne. Seventeen out of 329 patients screened for BKPyV from January 2009 to October 2013 were detected BKPyV positive in urine only, whereas in 23 patients the virus became additionally detectable in plasma. Among these, ten patients progressed to PyVAN. Overall, the present study showed that the detection from the third month onwards after transplantation of a first viruric episode with a median viral load of 1 × 10(8) copies/mL, followed after few days by a first viremi...Continue Reading

References

Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Emilio RamosMatthew R Weir
Aug 16, 2002·The New England Journal of Medicine·Hans H HirschJürg Steiger
Dec 4, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cinthia B DrachenbergEmilio Ramos
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans H Hirsch
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel L BohlDaniel C Brennan
May 2, 2006·TheScientificWorldJournal·Christine WuJerry McCauley
Jun 1, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C B Drachenberg, J C Papadimitriou
Oct 26, 2006·Journal of Medical Virology·Andi KrumbholzPeter Wutzler
Oct 27, 2006·Nature Clinical Practice. Nephrology·Peter LiptakBela Ivanyi
Jan 9, 2007·Microbes and Infection·Huai-Ying ZhengYoshiaki Yogo
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Daniel L Bohl, Daniel C Brennan
Aug 19, 2007·Journal of Virology·Aisling S DuganWalter J Atwood
Nov 26, 2008·Journal of Medical Virology·Ellen KrautkrämerMartin Zeier
Dec 9, 2008·Current Opinion in Organ Transplantation·Patrizia ComoliFabrizio Ginevri
May 13, 2009·The Journal of Infectious Diseases·Adrian EgliHans H Hirsch
Jun 25, 2009·Journal of Medical Virology·Renzo BoldoriniValeria Pietropaolo
Sep 26, 2009·Journal of Cellular Physiology·Sara TremoladaPasquale Ferrante
Jan 23, 2010·American Journal of Clinical Pathology·Charles J BechertJianli Dong
Nov 30, 2010·Nefrología : publicación oficial de la Sociedad Española Nefrologia·D BurgosD Hernández
Mar 10, 2012·Microbes and Infection·Shauna M BennettMichael J Imperiale
May 26, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Adnan SharifEdward Kraus
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
May 24, 2013·The American Journal of the Medical Sciences·Sarat KuppachiKenneth E Kokko
Jun 19, 2013·Journal of Medical Virology·Wassim Chehadeh, Mangalathillam Raman Nampoory
Oct 3, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kosuke MasutaniParmjeet Randhawa
Jul 24, 2014·Medical Microbiology and Immunology·B J D WeistN Babel
Nov 2, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I LautenschlagerH Jalanko

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Citations

Jul 5, 2015·Medical Microbiology and Immunology·Shahla AkhgariAmitis Ramezani
Oct 21, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Emine Nilufer BroedersPierre Vereerstraeten
Mar 16, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Neerja AgrawalMichelle A Josephson
Apr 13, 2017·European Journal of Haematology·Konstantin HöllerVeronica Di Cristanziano
Jul 27, 2018·Transplantation·Herman F WunderinkMariet C W Feltkamp
Feb 6, 2021·Pathogens·Yasuhito Funahashi

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