Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Stefan EngelhardtLutz Hein

Abstract

Chronic stimulation of cardiac beta1-adrenergic receptors contributes to disease progression and mortality in patients and animal models of heart failure. To search for the mechanism of adrenergic impairment of cardiac function in vivo, we studied transgenic mice with cardiac-specific overexpression of beta1-adrenergic receptors. Transgenic mice with cardiac overexpression of beta1-adrenergic receptors showed progressive left ventricular fibrosis starting at 4 months of age. Left ventricular catheterization revealed a modest enhancement of contractility and relaxation at 2 months of age, followed by progressive dysfunction in both parameters and ultimately cardiac failure. When the effects of endogenous catecholamines were blocked by the b-receptor antagonist propranolol, maximal rate of contractility (dp/dtmax) and maximal rate of relaxation (dp/dtmin) were significantly blunted in 2-month-old beta1-receptor transgenic mice. Isolated cardiomyocytes from these animals displayed markedly altered calcium transients with significant prolongation of the intracellular calcium transient compared with nontransgenic littermates. We determined the expression of sarcoplasmic reticulum proteins involved in calcium handling by RNase protec...Continue Reading

References

Apr 1, 1985·Journal of Molecular and Cellular Cardiology·G Rona
Dec 1, 1993·Pharmacology & Therapeutics·O E Brodde
Jan 5, 1996·The Journal of Biological Chemistry·W GuoK P Campbell
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·D K RohrerB K Kobilka
Dec 1, 1996·Circulation Research·K L Koss, E G Kranias
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A AkhterW J Koch
Apr 29, 1998·The Journal of Clinical Investigation·L R JonesM Morad
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·H A RockmanW J Koch
Oct 28, 1998·Physiological Reviews·H K Simmerman, L R Jones
Nov 4, 1998·Journal of Molecular and Cellular Cardiology·J NeumannL R Jones
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·S EngelhardtM J Lohse
Aug 12, 1999·European Journal of Pharmacology·C GiesslerO E Brodde
Nov 26, 1999·Circulation Research·R P XiaoE G Lakatta
Feb 7, 2001·Clinical Cardiology·B D LowesM R Bristow
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·J D BisognanoD J Port
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D C WhiteW J Koch
Nov 9, 2000·The Journal of Biological Chemistry·U KirchheferL R Jones
Feb 13, 2001·Journal of Molecular and Cellular Cardiology·L ZhangL R Jones
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·V B HardingH A Rockman

❮ Previous
Next ❯

Citations

Nov 24, 2006·Basic Research in Cardiology·Ute SeelandMichael Böhm
Aug 6, 2003·Trends in Molecular Medicine·Oliver Ritter, Ludwig Neyses
Oct 24, 2012·Nature Reviews. Cardiology·Changwon KhoRoger J Hajjar
Feb 4, 2010·Circulation·Anne-Marie LompréAndrew R Marks
Aug 19, 2007·The Journal of Clinical Investigation·Hiroyuki NakayamaJeffery D Molkentin
Mar 27, 2012·Heart Failure Reviews·A C GomesA F Leite-Moreira
Jun 21, 2005·Pharmacology & Therapeutics·Tomie KawadaTeruhiko Toyo-Oka
Mar 28, 2007·Heart Failure Clinics·Stefan Engelhardt
Jun 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Uwe KirchheferJoachim Neumann
Nov 15, 2003·Circulation Research·Martin J LohseThomas Eschenhagen
Feb 14, 2019·British Journal of Pharmacology·Xiao-Jun DuHelen Kiriazis
Aug 29, 2006·Anais Da Academia Brasileira De Ciências·Patricia C BrumAlessandra Medeiros
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ulrich GergsJoachim Neumann
Nov 11, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Catherine E HugginsLea M D Delbridge
May 1, 2009·The Journal of Physiology·Tracy J Pritchard, Evangelia G Kranias
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chang-Soo HongDo Han Kim
Dec 25, 2002·The Journal of Veterinary Medical Science·Masami UechiMasashi Mizuno
Dec 5, 2020·International Journal of Endocrinology·Abril Carbajal-GarcíaLuis M Montaño
Nov 4, 2006·European Journal of Pharmacology·Peter J Greasley, John C Clapham
Mar 28, 2007·Heart Failure Clinics·Djamel LebecheRoger J Hajjar
Jan 22, 2008·Trends in Cardiovascular Medicine·Guo-Chang FanEvangelia G Kranias

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Qunying YuanEvangelia G Kranias
Biochemical and Biophysical Research Communications
C S HongDo H Kim
American Journal of Physiology. Heart and Circulatory Physiology
Ulrich GergsJoachim Neumann
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Chang-Soo HongDo Han Kim
© 2021 Meta ULC. All rights reserved