Early Improvement and Marriage Are Determinants of the 12-Month Treatment Outcome of Paroxetine in Outpatients with Panic Disorder

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Takashi WatanabeKazutaka Shimoda

Abstract

In this study, we investigated the determinants of remission and discontinuation of paroxetine pharmacotherapy in outpatients with panic disorder (PD). Subjects were 79 outpatients diagnosed with PD who took 10-40 mg/day of paroxetine for 12 months. The candidate therapeutic determinants included the serotonin transporter gene-linked polymorphic region and the -1019C/G promoter polymorphism of the serotonin receptor 1A as genetic factors, educational background and marital status as environmental factors, and early improvement (EI) at 2 weeks as a clinical factor were assessed. The Clinical Global Impression scale was used to assess the therapeutic effects of the pharmacotherapy. Cox proportional hazards regression was performed to investigate the significant predictive factors of remission and discontinuation. EI was only a significant predictive factor of remission. EI was a significant predictive factor of remission (hazard ratio [HR], 2.709; 95% confidence interval [CI], 1.177-6.235). Otherwise, EI and marital status were significant predictive factors of the discontinuation. EI (HR, 0.266; 95% CI, 0.115-0.617) and being married (HR, 0.437; 95% CI, 0.204-0.939) were considered to reduce the risk of treatment discontinuation...Continue Reading

References

May 1, 1989·The American Journal of Psychiatry·C Faravelli, S Pallanti
Dec 1, 1985·The American Journal of Psychiatry·C FaravelliA Sessarego
Oct 1, 1983·Archives of General Psychiatry·E L HarrisD R Chaudhry
Oct 1, 1983·Archives of General Psychiatry·R R CroweD Slymen
Aug 1, 1993·Acta Psychiatrica Scandinavica·I SkreE Kringlen
Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Oct 2, 2001·The American Journal of Psychiatry·J M HettemaK S Kendler
Jul 11, 2002·Social Psychiatry and Psychiatric Epidemiology·Per CarlbringGerhard Andersson
Jul 30, 2003·Archives of General Psychiatry·M R Mavissakalian, J M Perel
Feb 27, 2004·The International Journal of Neuropsychopharmacology·Claudia RotheKlaus-Peter Lesch
Nov 10, 2004·Journal of Anxiety Disorders·Roger MarcaurelleNicole Mainguy
Apr 29, 2005·Psychological Medicine·Stephen B ManuckMatthew F Muldoon
Jul 22, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giampaolo PernaLaura Bellodi
Dec 1, 2005·The International Journal of Neuropsychopharmacology·Katharina DomschkeJürgen Deckert
Mar 16, 2006·Psychiatric Genetics·Christine M FreitagJürgen Deckert
Apr 6, 2006·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Jul 22, 2008·Neuropharmacology·Brice Le FrançoisPaul R Albert
Jun 21, 2011·European Journal of Clinical Pharmacology·Shin IshiguroKazutaka Shimoda
Dec 27, 2011·Journal of Clinical Psychopharmacology·Antonio E NardiMarcio Versiani
Feb 23, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Kwan-Woo ChoiBum-Hee Yu
May 31, 2014·Journal of Clinical Psychopharmacology·Faruk UguzRustem Askin
Sep 27, 2014·Neuropsychiatric Disease and Treatment·Akiko AokiKazutaka Shimoda
Jun 18, 2015·Social Psychiatry and Psychiatric Epidemiology·Ramin MojtabaiRonald C Kessler
Feb 6, 2016·The Journal of Clinical Psychiatry·Jafar BakhshaieRenee D Goodwin
Apr 18, 2016·Journal of Affective Disorders·Borah KimSang-Hyuk Lee
Apr 29, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Kang-Seob OhSe-Won Lim

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pharmacotherapy
Genotyping
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