Early improvement in depressive symptoms with desvenlafaxine 50 mg/d as a predictor of treatment success in patients with major depressive disorder

Journal of Clinical Psychopharmacology
Claudio N SoaresChristine J Guico-Pabia

Abstract

This post hoc analysis assessed the predictive value of improvement in depressive scores at early time points for treatment outcomes at week 8 in patients with major depressive disorder treated with desvenlafaxine 50 mg/d or placebo. Pooled data from 6 double-blind, fixed-dose studies in adult patients with major depressive disorder. Patients were randomly assigned to desvenlafaxine or placebo. Primary end point was change in 17-item Hamilton Rating Scale for Depression (HAM-D17) scores from baseline to week 8 (or last observation carried forward). Optimal thresholds of improvement (percent change from baseline HAM-D17) at weeks 2 and 3 for predicting 4 levels of treatment success (≥ 45%, ≥ 50%, and ≥ 65% decrease from baseline HAM-D17, HAM-D17 ≤ 7) at week 8 (last observation carried forward) were determined using receiver operating characteristic analysis. Odds ratios of the predictability of improvement thresholds were computed from a logistic regression model adjusting for significant baseline predictors. Desvenlafaxine 50 mg/d (n = 1207) had significantly greater rates of treatment success for each level of treatment success at 8 weeks compared with placebo (n = 1067). Optimal early improvement thresholds for weeks 2 (20%-...Continue Reading

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Citations

Jun 11, 2014·Expert Opinion on Pharmacotherapy·Susan G KornsteinMatthieu Boucher
Nov 28, 2018·Journal of Geriatric Psychiatry and Neurology·Caroline Masse-SibilleChopard Gilles
Jan 9, 2020·Journal of Psychopharmacology·Martin A KatzmanMatthieu Boucher
Feb 20, 2016·International Clinical Psychopharmacology·José L CarrascoMatthieu Boucher
Mar 4, 2014·International Clinical Psychopharmacology·Raymond W LamMatthieu Boucher
Mar 3, 2017·Indian Journal of Psychological Medicine·Pranjali P MendheMinakshi N Parikh
Oct 13, 2017·The International Journal of Neuropsychopharmacology·Oloruntoba J OlubokaPierre Blier

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