Early Improvements in insulin sensitivity and inflammatory markers are induced by pravastatin in nondiabetic subjects with hypercholesterolemia

Clinica Chimica Acta; International Journal of Clinical Chemistry
Wen-Jane LeeWayne Huey-Herng Sheu

Abstract

Statins may improve lipid profiles and inflammation-associated biomarkers, but the effect on insulin sensitivity is controversial. We investigated the effects of 2 doses of pravastatin (40 and 10 mg/day) on insulin sensitivity and serum inflammatory markers in nondiabetic hypercholesterolemic patients. This was a randomized, parallel, comparative design study. A total of 40 nondiabetic subjects with elevated low-density lipoprotein (LDL) cholesterol were randomized to either the 40 mg pravastatin/day group (n=21) or the 10 mg pravastatin/day group (n=19) for 8 weeks. The fasting serum lipid profile, homeostasis model assessment (HOMA), glucose and insulin response of the two-hour glucose tolerance test (2 h-OGTT), and several inflammatory markers were determined. Eight weeks of pravastatin treatment in both dose groups led to a significant reduction in serum LDL cholesterol, total cholesterol, triglycerides, and total cholesterol/ high-density lipoprotein (HDL) cholesterol ratios (all p< 0.01 in 40 mg group and all p<0.05 in 10 mg group), though the 40 mg group had greater effects. Although the fasting HOMA insulin resistance did not change significantly in either group, glucose and insulin areas under the curve of 2 h-OGTT wer...Continue Reading

References

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Jan 6, 2006·Journal of Atherosclerosis and Thrombosis·Kyoko OkadaJun Hayashi

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Citations

Aug 9, 2013·Antioxidants & Redox Signaling·Soo LimKwang Kon Koh
Apr 5, 2011·Cardiology Research and Practice·Yi-Jing Sheen, Wayne Huey-Herng Sheu
Mar 21, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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