Early increase in phosphatidyl choline synthesis by choline and transmethylation pathways in spreading fibroblasts

Experimental Cell Research
C MazièreJ Polonovski

Abstract

Phosphatidyl choline (PC) synthesis in trypsinized and reattaching fibroblasts during the spreading state was studied by incorporation of [14C]choline and [methyl-14C]methionine. The choline and phosphatidyl-ethanolamine (PE) transmethylation pathways were both transiently increased about 2-fold during the first 2 h after replating. Maximum increase appeared to be simultaneous with maximum spreading. Incorporation of [32P]orthophosphate showed that the increase in PC synthesis was specific and most probably related to establishment of cell-substrate adhesion sites.

References

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Citations

Jul 1, 1988·Biochimica Et Biophysica Acta·H G LileyP L Ballard

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