PMID: 8938550Nov 1, 1996Paper

Early increase in plasma parathyroid hormone levels following liver transplantation

Journal of Hepatology
J E CompstonG Alexander

Abstract

The pathogenesis of post-transplantation bone loss is poorly understood, although glucocorticoid therapy is believed to play an important role. In the present study we have measured plasma parathyroid hormone concentrations in the first few months after orthotopic liver transplantation, in order to examine the potential contribution of hyperparathyroidism to bone disease. Twenty-seven patients aged 32-54 years, 12 male, undergoing liver transplantation were studied prospectively before and for 3 months after operation. Plasma parathyroid hormone and serum 25-hydroxyvitamin D concentrations were measured by radioimmunoassay. Plasma parathyroid hormone levels were normal in all but two patients prior to transplantation. There was a highly significant increase in plasma parathyroid hormone concentrations at 1 and 2 months (p < 0.0005 and 0.001, respectively, versus baseline); by 3 months, values were close to those obtained preoperatively. Serum 25-hydroxyvitamin D concentrations showed no significant change over the study period. However, 74% of the patients had subnormal values at baseline. An early and transient increase in plasma parathyroid hormone after liver transplantation may be responsible for the high rates of bone loss...Continue Reading

References

Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R EastellR A Krom
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A McDonaldG W McCaughan
Feb 1, 1988·Journal of Hepatology·E B HaagsmaC H Gips
Sep 30, 1995·Lancet·N K HendersonJ A Eisman
Sep 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P N SambrookJ A Eisman
Jul 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F CosmanR Lindsay
Dec 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E MeysP J Meunier
Jan 20, 2004·Seminars in Nephrology·Stuart M Sprague, Michelle A Josephson

❮ Previous
Next ❯

Citations

Jul 3, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A FloreaniR Naccarato
Jan 6, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M Stein, E Shane
Sep 1, 2006·Rheumatology International·Pietra PennisiCarmelo E Fiore
Apr 20, 2006·Journal of Bone and Mineral Metabolism·Chie WadaToshihiko Nagata
Sep 2, 2003·Gastroenterology·William D LeslieUNKNOWN American Gastroenterological Association Clinical Practice Commitee
Jul 9, 2002·Clinical Transplantation·Marc WalterBurghard F Klapp
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S VediJ E Compston
Sep 8, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·F H WolfhagenS W Schalm
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maureen M J GuichelaarJ Eileen Hay
Nov 17, 2001·European Journal of Gastroenterology & Hepatology·S GianniniG Crepaldi
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rajesh N KeswaniEmmet B Keeffe
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Juliet E Compston
Aug 26, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maureen M J GuichelaarJ Eileen Hay
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maureen M J GuichelaarJ Eileen Hay
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Peter P ReeseMary B Leonard
Feb 26, 2000·The Journal of Clinical Endocrinology and Metabolism·E O AbuJ E Compston
Jan 16, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Leon Fisher, Alexander Fisher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A FloreaniG Luisetto
The American Journal of Medicine
E MeysP D Delmas
© 2021 Meta ULC. All rights reserved