Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats

Biochimie
Emilie DistelChantal Benelli

Abstract

The epicardial adipose tissue (EAT) is "hypertrophied" in the obese. Thiazolidinediones are anti-diabetic, hypolipidemic drugs and are selective agonists for the gamma isoform of peroxisome proliferator-activated receptor (PPARγ). We evaluated the short-term effects of the prototype rosiglitazone (RSG, 5 mg kg(-1) day(-1) for 4 days) on the expression of the genes and proteins (by real-time PCR and Western blot) involved in fatty acid (FA) metabolism in EAT of the obese fatty Zucker rat and compared the levels of expression with those in retroperitoneal adipose tissue (RAT). The glyceroneogenic flux leading to fatty acid re-esterification was assessed by the incorporation of 14C from [1-14C]-pyruvate into neutral lipids. RSG upregulated the mRNA for phosphoenolpyruvate carboxykinase, pyruvate dehydrogenase kinase 4, glycerol kinase, adipocyte lipid binding protein, adipose tissue triglyceride lipase and lipoprotein lipase in both RAT and EAT with a resulting increase in glyceroneogenesis that, however, was more pronounced in EAT than in RAT. Under RSG, fatty acid output was decreased in both tissues but unexpectedly less so in EAT than in RAT. RSG also induced the expression of the key genes for fatty acid oxidation [carnitinep...Continue Reading

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Citations

Nov 26, 2013·Endocrine·Gianluca Iacobellis
Aug 19, 2014·Differentiation; Research in Biological Diversity·Sujith RajanAnil Nilkanth Gaikwad
Sep 26, 2013·The Journal of Veterinary Medical Science·Hiroki AsanoMasayuki Funaba
Feb 6, 2016·Current Opinion in Pharmacology·Gianluca Iacobellis
Sep 19, 2015·Biochemical and Biophysical Research Communications·Qianqian MuSihua Gao
Aug 21, 2014·Diabetes/metabolism Research and Reviews·Jianfei FuXiaohong Zhang
Apr 9, 2015·Nature Reviews. Endocrinology·Gianluca Iacobellis
Jul 20, 2016·European Journal of Nutrition·Jae Heon ChoiJong Won Yun
Jun 21, 2018·Journal of Internal Medicine·F VillarroyaM Giralt
Nov 5, 2019·Pacing and Clinical Electrophysiology : PACE·Mengmeng ZhouLiang Zhao
May 7, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Teresa BejarLina Badimon
Sep 27, 2018·World Journal of Diabetes·Eleni XourgiaAndreas Melidonis
Aug 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bàrbara ReynésAndreu Palou
Jul 19, 2017·Xenotransplantation·Kefeng YangOuliana Ziouzenkova
Dec 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haichuan PengXiaolei Wang

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