Early induction of the NGFI-B/Nur77 family genes in nephritis induced by anti-glomerular basement membrane antibody

Molecular and Cellular Endocrinology
K HayashiY Tomino

Abstract

We recently isolated a novel nuclear receptor NOR-1, which is a member of the steroid/thyroid receptor superfamily, and belongs to the NGFI-B/Nur77 family. In the present study, we examined gene expression of NOR-1 and its closely related members in nephritis induced by anti-glomerular basement membrane (GBM) antibody. The mRNA levels for NOR-1, NGFI-B and RNR-1 increased 24 h after injection of anti-GBM antibody (day 1). Gene expression of NOR-1 and NGFI-B reached maximum levels on day 3, gradually decreased thereafter and returned to control levels on day 28. RNR-1 reached a peak on day 7, and then decreased. Renal injuries were most prominent on day 7 and persisted until day 28, indicating that NOR-1, NGFI-B and RNR-1 genes are induced during the early stage of glomerulonephritis and may be associated with the progression of glomerulonephritis. The induction of the NGFI-B gene was less remarkable than that of NOR-1 and RNR-1. In addition, administration of glucocorticoid hormone suppressed NOR-1 and RNR-1 gene expression to almost normal levels, whereas NGFI-B gene expression was not significantly repressed. These findings also suggest that the NGFI-B/Nur77 family may possess different biological roles and NGFI-B might act a...Continue Reading

References

May 18, 1995·The New England Journal of Medicine·G P Chrousos
Dec 30, 1994·Biochemical and Biophysical Research Communications·N OhkuraK Miki

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Citations

Mar 8, 2006·The Journal of Experimental Medicine·Huiyan ZengHarold F Dvorak
Feb 22, 2012·Journal of the American Society of Nephrology : JASN·Savithri BalasubramanianTerry B Strom
Oct 26, 1999·Endocrine Reviews·V Giguère
Jul 13, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shengqiang ZhaoHuiyan Zeng
Dec 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xin LiuHuiyan Zeng

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