Abstract
Multiorgan failure is the main cause of death in patients operated for ruptured abdominal aortic aneurysm (rAAA). The systemic inflammatory response plays a central role in the generation and maintenance of multiorgan dysfunction. The aim of the current study was to investigate the inflammatory response preoperatively in patients with ruptured and nonruptured AAA in relation to the clinical outcome. A total of 95 patients about to undergo repair of AAA (43 ruptured with shock, 12 ruptured without shock, and 40 elective) and 41 controls without aneurysm matched by age, gender, and smoking habits were investigated by inflammatory markers. There were significantly higher levels of interleukin 6 (IL-6; proinflammatory cytokine) and IL-10 (anti-inflammatory cytokine) in patients operated for ruptured compared to nonruptured AAA. In conclusion, the current data indicate that rupture of an AAA activates the inflammatory system with a compensatory anti-inflammatory response.
References
Feb 1, 1991·Journal of Vascular Surgery·E S Crawford
Dec 1, 1993·Annals of Surgery·R M RoumenR J Goris
Apr 1, 1996·Acta Anaesthesiologica Scandinavica·M KristianssonK G Sundqvist
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J JuvonenT Juvonen
Apr 16, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A HolmbergA Siegbahn
Apr 19, 2000·Circulation·P M RidkerC H Hennekens
Jun 10, 2000·Shock·T S HuberL L Moldawer
Oct 14, 2000·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·J R BoyleM M Thompson
Jan 13, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·V TreskaL Pecen
May 23, 2001·Circulation·K G JonesJ T Powell
May 16, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P SwartbolL Norgren
Oct 2, 2001·The British Journal of Surgery·T E Rowlands, S Homer-Vanniasinkam
Dec 12, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J BownR D Sayers
Apr 12, 2002·American Journal of Surgery·Christopher D RaeburnAlden H Harken
Apr 20, 2005·Lancet·David A Grimes, Kenneth F Schulz
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
May 4, 2005·Lancet·N SakalihasanO D Defawe
Citations
Sep 24, 1999·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·S R WalkerB R Hopkinson
Apr 10, 2015·Annals of Medicine·Mengyang LiaoGuo-Ping Shi
Aug 27, 2013·Annals of Vascular Surgery·Jiang XiongTao Zhang
Jan 17, 2012·Vascular Pharmacology·Svitlana DemyanetsJohann Wojta
Mar 17, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P SukV Sramek
Mar 22, 2014·Annals of Surgery·Sean J EnglishGilbert R Upchurch
Mar 4, 2020·BMC Surgery·Mitra SadeghiKristofer F Nilsson