Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation

International Journal of Cardiology
Elli StefanadiC Stefanadis

Abstract

High-dose statin treatment improves clinical outcome of ST-elevated myocardial infarction (STEMI). However, the effect of low-dose atorvastatin treatment on inflammatory and pro-thrombotic molecules during the post-STEMI period is unclear. We investigated the effect of low-dose atorvastatin treatment on the kinetics of cytokine IL-6, vascular cell adhesion molecule (sVCAM-1) and endothelium-derived markers of thrombosis/fibrinolysis such as von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA), post STEMI. Twenty-four normocholesterolemic patients with STEMI were randomised to receive atorvastatin 10mg/day or no statin treatment for 6 weeks after the event. Blood samples were obtained by their admission to the hospital as well as at weeks 1 and 6. Circulating levels of IL-6, sVCAM-1, vWF, PAI-1 and tPA were determined by ELISA. Atorvastatin induced a decrease of IL-6 at 1 week, an effect which reached significance compared to baseline at 6 weeks post STEMI (p<0.05 vs baseline). Serum sVCAM-1 was increased in controls both at 1 and 6 weeks post-STEMI (p<0.05 vs baseline), an effect prevented by atorvastatin. Plasma vWF was increased 1 week post-STEMI in controls (p<0.05 vs ...Continue Reading

References

Mar 1, 2006·Atherosclerosis. Supplements·Matthias Endres
Jun 6, 2006·Cytokine & Growth Factor Reviews·Dimitris TousoulisChristodoulos Stefanadis

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Citations

Dec 20, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayoshi KiyokuniKazuo Kimura
Feb 5, 2016·European Heart Journal·Dimitris TousoulisJuan Carlos Kaski
Sep 2, 2014·The Cochrane Database of Systematic Reviews·Noah ValeMatthias Briel
Jan 23, 2021·The Cochrane Database of Systematic Reviews·Muhammad Ismail ShawishJames M Wright
Jun 11, 2010·Current Opinion in Cardiology

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