Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali

The Journal of Infectious Diseases
Matthew B B McCallRobert W Sauerwein

Abstract

Interethnic differences in susceptibility to malaria provide a unique opportunity to explore immunological correlates of protection. The Fulani of Sahelian Africa are known for their reduced susceptibility to Plasmodium falciparum, compared with surrounding tribes, yet the immunology underlying this is still poorly understood. Here, we show that mononuclear cells from Fulani elicit >10-fold stronger interferon (IFN)-gamma production following a 24-h in vitro coincubation with asexual parasites than cells from sympatric Dogon. This response appears to be specific for P. falciparum among a panel of other human pathogens and is independent of the lower number of regulatory T cell counts present in Fulani. IFN-gamma responses in both tribes were inversely correlated with peripheral parasite density as quantified by nucleic acid sequenced-based amplification, but responses of Fulani remained significantly stronger than those of Dogon after adjustment for concurrent parasitemia, suggesting that hard-wired immunological differences underlie the observed protection. These results underscore the value of early IFN-gamma responses to P. falciparum as a correlate of anti-parasite immunity, not only in this setting but also in the wider co...Continue Reading

Citations

Oct 12, 2012·Bulletin de la Société de pathologie exotique·A DoloO Doumbo
Jan 18, 2011·Malaria Journal·A Inkeri LokkiVille Holmberg
Jan 15, 2014·PLoS Pathogens·Prasanna JagannathanMargaret E Feeney
Nov 24, 2011·International Journal of Biological Sciences·Douglas J PerkinsJohn Michael Ong'echa
Jan 9, 2016·Parasitology·Danielle I Stanisic, Michael F Good
Jun 7, 2014·Frontiers in Microbiology·Michelle N WykesDeshapriya S Karunarathne
Apr 21, 2017·PloS One·Evans RaballahJohn Michael Ong'echa
Jul 9, 2010·Journal of Leukocyte Biology·Matthew B B McCall, Robert W Sauerwein
Oct 2, 2015·PLoS Pathogens·Thayer King, Tracey Lamb
Oct 15, 2019·Immunological Reviews·Claire LoiseauDenise L Doolan
Mar 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon MetenouThomas B Nutman
Jul 12, 2020·Scandinavian Journal of Immunology·Marita Troye-BlombergAnn-Kristin Östlund Farrants
Sep 7, 2017·Scientific Reports·Norinne Lacerda-QueirozXin-Zhuan Su
Nov 2, 2019·Immunological Reviews·Rajiv KumarChristian R Engwerda
Aug 31, 2018·Frontiers in Immunology·Charles AramaOgobara K Doumbo
Apr 17, 2020·Trends in Parasitology·Benoît HenryPierre Buffet
Jun 12, 2021·Nature Metabolism·Wael AbdrabouYoussef Idaghdour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.