Early intervention exercise training does not delay prostate cancer progression in Pten-/- mice

The Prostate
Renea A TaylorMatthew J Watt

Abstract

There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of exercise therapy, although there is limited preclinical, and no clinical, data to directly support the notion that exercise training improves prostate cancer prognosis or outcome. The aim of this study was to investigate the effect of regular exercise training on the early stages of prostate cancer progression, as well as assessing whether alterations to prostate cancer metabolism are induced by exercise. Mice with prostate-specific deletion of Pten (Pten-/- ) remained sedentary or underwent 6 weeks of endurance exercise training or high-intensity exercise training involving treadmill running. At the conclusion of the training period, the prostate lobes were excised. A portion of fresh tissue was used to assess glucose, glutamine, and fatty acid metabolism by radiometric techniques and a second portion was fixed for histopathology. Despite the implementation of an effective exercise regime, as confirmed by improvements in running capacity, neither prostate mass, cell proliferation or the incidence of high-grade prostate intraepithelial hyperplasia or noninvasive carcinoma in situ were significantly different be...Continue Reading

References

Jan 1, 1995·International Journal of Technology Assessment in Health Care
Aug 8, 2001·The Journal of Urology·C N TymchukW J Aronson
Aug 12, 2005·The Journal of Urology·Dean OrnishPeter R Carroll
Apr 11, 2006·Nature Medicine·Matthew J WattGregory R Steinberg
Dec 6, 2006·Medicine and Science in Sports and Exercise·Daniel A GalvãoRobert U Newton
Jul 4, 2007·The Journal of Clinical Investigation·Isabelle M BerquinYong Q Chen
Apr 21, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Sherry SolimanR James Barnard
Jun 3, 2009·The Prostate·Karyn A EsserAlan M Diamond
Jul 2, 2009·Medicine and Science in Sports and Exercise·Lisa H ColbertStephen D Hursting
Sep 18, 2009·The Journal of Urology·Jodi A AntonelliStephen J Freedland
Apr 29, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giorgia ZadraMassimo Loda
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stacey A KenfieldJune M Chan
May 19, 2012·Journal of Applied Physiology·Lee W JonesStephen J Freedland
May 1, 2013·The Prostate·Avi D VandersluisVasundara Venkateswaran
Jul 19, 2013·PloS One·Helene RundqvistArne Östman
Oct 20, 2015·Progress in Molecular Biology and Translational Science·Thomas Tsiloulis, Matthew J Watt
Nov 20, 2015·Endocrine Connections·Renea A TaylorMatthew J Watt
Mar 10, 2016·Nature Reviews. Urology·Daniel A GalvãoRobert U Newton
Apr 28, 2016·American Journal of Physiology. Endocrinology and Metabolism·Emmanuel DenouJonathan D Schertzer
Jul 8, 2016·Science Advances·Ralph J DeBerardinis, Navdeep S Chandel
Jul 9, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brian D HayesStephen P Finn
Aug 4, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J RebelloLuc Furic
Oct 18, 2016·The Journal of Physiology·Martin J MacInnis, Martin J Gibala
Dec 20, 2017·Oncotarget·Oliver K GlassVictoria Seewaldt
Feb 21, 2018·Nature Reviews. Urology·Tamara JamaspishviliTamara L Lotan
Mar 24, 2018·The Prostate·Christian CamposAlejandro S Godoy
May 18, 2018·Medicine and Science in Sports and Exercise·Matthew J StorkKathleen A Martin Ginis
Feb 8, 2019·Science Translational Medicine·Matthew J WattRenea A Taylor
Jan 9, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kim EdmundsRobert U Newton
Jan 11, 2020·Journal of Sport and Health Science·Shanshan GuoTiemin Liu

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Citations

Apr 14, 2021·Journal of Physical Activity & Health·Mário EstevesJosé A Duarte

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