Early, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarction

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
A C MitsiTheofilos M Kolettis

Abstract

Ventricular remodeling is a common corollary of myocardial infarction. We hypothesized that this process may be attenuated by growth hormone, administered as a single high-dose, selectively in the infarct zone, early postmyocardial infarction. In 35 pigs (29+/-4 kg), myocardial infarction was generated by inflation of an over-the-wire angioplasty balloon in the circumflex artery for 60 min and 5 further pigs were sham-operated. Ten minutes after reperfusion, the pigs were randomized (2:1) to either growth hormone (1 IU/kg) (n=23) or normal saline (n=12), delivered via the balloon catheter. All survivors were treated with captopril and were sacrificed 4 weeks after myocardial infarction. Compared to controls, growth hormone-treated animals displayed lower heart weight (4.1+/-0.5 g/kg body weight, versus 3.4+/-0.4 g/kg, respectively, p=0.003) and dimensions (left ventricular short axis diameter 46+/-7 mm versus 37+/-6 mm, p=0.01; right ventricular short axis diameter 38+/-7 mm versus 30+/-5 mm p=0.001). Growth hormone increased wall thickness in the infarct (6.0+/-1.8 in controls versus 9.9+/-3.7 in treated animals, p=0.004) and non-infarct zones (10.6+/-1.8 in controls versus 15.5+/-3.8 in treated animals, p=0.0006) and produced...Continue Reading

References

Mar 4, 2000·The New England Journal of Medicine·S H LeeP A Thistlethwaite
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Aug 7, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A S KhanW E Sonntag
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A TivestenJ Isgaard
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Hongkui JinNicholas F Paoni
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Matthias NahrendorfGeorg Ertl

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Citations

Aug 21, 2015·Growth Factors·Evangelos P DaskalopoulosTheofilos M Kolettis
Sep 25, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·K E HatzistergosV Malamou-Mitsi
Sep 16, 2011·International Journal of Cardiology·Agapi D VilaetiTheofilos M Kolettis
Jan 7, 2010·Journal of Cardiovascular Pharmacology·Fernanda D OleaAlberto Crottogini
Feb 6, 2020·International Journal of Molecular Sciences·Konstantinos V StamatisTheofilos M Kolettis

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