Early Intravascular Events Are Associated with Development of Acute Respiratory Distress Syndrome. A Substudy of the LIPS-A Clinical Trial

American Journal of Respiratory and Critical Care Medicine
Raja-Elie E AbdulnourBruce D Levy

Abstract

Acute respiratory distress syndrome (ARDS) is a devastating illness with limited therapeutic options. A better understanding of early biochemical and immunological events in ARDS could inform the development of new preventive and treatment strategies. To determine select peripheral blood lipid mediator and leukocyte responses in patients at risk for ARDS. Patients at risk for ARDS were randomized as part of a multicenter, double-blind clinical trial of aspirin versus placebo (the LIPS-A [Lung Injury Prevention Study with Aspirin] trial; NCT01504867). Plasma thromboxane B2 (TXB2), aspirin-triggered lipoxin A4 (15-epi-LXA4, ATL), and peripheral blood leukocyte number and activation were determined on enrollment and after treatment with either aspirin or placebo. Thirty-three of 367 subjects (9.0%) developed ARDS after randomization. Baseline ATL levels, total monocyte counts, intermediate monocyte counts, and monocyte-platelet aggregates were associated with the development of ARDS. Peripheral blood neutrophil count and monocyte-platelet aggregates significantly decreased over time. Of note, nine subjects developed ARDS after randomization yet before study drug initiation, including seven subjects assigned to aspirin treatment. S...Continue Reading

Associated Clinical Trials

Jan 6, 2012·Daryl J. Kor, M.D., Daryl J. Kor, M.D.

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·J Clària, C N Serhan
Oct 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nan ChiangCharles N Serhan
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koichi FukunagaBruce D Levy
Dec 5, 2006·The Journal of Clinical Investigation·Wolfgang M Kuebler
Dec 5, 2006·The Journal of Clinical Investigation·Alexander ZarbockKlaus Ley
Feb 5, 2010·Mucosal Immunology·A PlanagumàB D Levy
Aug 31, 2010·American Journal of Respiratory and Critical Care Medicine·Ognjen GajicMichael Malinchoc
Feb 1, 2011·American Journal of Respiratory and Critical Care Medicine·Susanne HeroldJuergen Lohmeyer
Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
Jul 24, 2012·American Journal of Respiratory and Critical Care Medicine·Kevin DhaliwalA John Simpson
Aug 2, 2012·The Journal of Clinical Investigation·Michael A MatthayGuy A Zimmerman
Sep 7, 2012·BMJ Open·Daryl Jon KorUNKNOWN US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A)
May 25, 2013·Circulation Research·Matthew T RondinaGuy A Zimmerman
Dec 10, 2013·Annual Review of Physiology·Bruce D Levy, Charles N Serhan
May 6, 2014·Cellular Immunology·Loems Ziegler-Heitbrock
Aug 28, 2014·American Journal of Respiratory and Critical Care Medicine·Emiko OnoUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Nov 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Raja-Elie E AbdulnourBruce D Levy
May 18, 2016·JAMA : the Journal of the American Medical Association·Daryl J KorUNKNOWN US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A)
Aug 12, 2016·American Journal of Respiratory and Critical Care Medicine·Katie R FamousUNKNOWN ARDS Network
Jan 4, 2017·American Journal of Respiratory and Critical Care Medicine·Hemang YadavOgnjen Gajic
Jun 14, 2017·The Journal of Experimental Medicine·Amit A PatelSimon Yona

❮ Previous
Next ❯

Citations

Mar 16, 2019·Nature Reviews. Disease Primers·Michael A MatthayCarolyn S Calfee
Jul 16, 2020·American Journal of Respiratory and Critical Care Medicine·Brijesh V PatelSujal R Desai
May 22, 2018·American Journal of Respiratory and Critical Care Medicine·Elizabeth A Middleton, Guy A Zimmerman
Apr 9, 2019·American Journal of Respiratory and Critical Care Medicine·Ivor S DouglasHayley B Gershengorn
Nov 30, 2019·Expert Opinion on Investigational Drugs·Pedro Leme SilvaPatricia R M Rocco
Aug 14, 2020·Expert Opinion on Pharmacotherapy·Maria Gabriella MateraMario Cazzola
Dec 17, 2020·Frontiers in Immunology·Luca CioccariMojgan Masoodi
Jan 1, 2021·International Journal of Molecular Sciences·Pradeesh SivapalanJens-Ulrik Jensen
Oct 31, 2020·Thrombosis and Haemostasis·Alexandre Le JoncourDavid Saadoun
Apr 24, 2021·PloS One·Kelly A BartigMats W Johansson
May 26, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne-Sophie ArchambaultNicolas Flamand
Jun 28, 2021·Cell Biochemistry and Biophysics·Julie Nijmeh, Bruce D Levy
Jan 19, 2022·JAMA : the Journal of the American Medical Association·Jeffrey S BergerUNKNOWN ACTIV-4a Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
blood draw
acetylation

Clinical Trials Mentioned

NCT01504867

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.