PMID: 7029461Nov 14, 1981Paper

Early jaundice after orthotopic liver transplantation. The role of ischaemia (author's transl)

La Nouvelle presse médicale
J BenichouP Monod Broca

Abstract

The purpose of this experimental study was to identify the cause of early cholestatic jaundice occurring after orthotopic liver transplantation. The role of ischaemia was investigated in dogs undergoing auto-transplantation of the liver preserved for two hours. The animals developed early cholestasis with lesions that were markedly different from the graft-rejection lesions observed in a control group, being restricted to the cells and canaliculi of the central lobular area. The results of this work have made it possible to avoid overdosage with immunosuppressive drugs in a patient who had recently undergone orthotopic liver transplantation.

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