Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study.

BMC Ophthalmology
Line KesselM Larsen

Abstract

Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging. A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard software. Lens aging was quantified by lens fluorometry. The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia. The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.

References

Feb 11, 1991·Archives of Ophthalmology·M C LeskeS Y Wu
Aug 1, 1989·Archives of Ophthalmology·S WestH R Taylor
Jun 1, 1984·Ophthalmology·L T Chylack
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V M MonnierA Cerami
Aug 16, 1996·The Journal of Biological Chemistry·J Bubeck WardenburgP R Findell
Aug 1, 1996·Diabetologia·T J SimsA J Bailey
Nov 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Z MakitaT Koike
Sep 23, 1997·Archives of Ophthalmology·R HillerR C Milton
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CeramiA Cerami
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·B H WolffenbuttelB I Lévy
Feb 16, 1999·Archives of Internal Medicine·M PahorW B Applegate
May 10, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·A Spector
Sep 23, 2000·Nature·A J Lusis
Mar 10, 2001·Recent Progress in Hormone Research·P Ulrich, A Cerami
Apr 27, 2001·American Journal of Epidemiology·F B HuW C Willett
Jun 14, 2002·Developments in Ophthalmology·Arsaell ArnarssonUNKNOWN Reykjavik Eye Study Group
Jun 13, 2003·Journal of Interventional Cardiology·Robert S SchwartzCheryl A Conover
Dec 10, 2003·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Torben JørgensenCharlotta Pisinger
Oct 17, 2009·The British Journal of Ophthalmology·Arsaell ArnarssonHiroshi Sasaki
Jan 10, 2013·Current Opinion in Lipidology·Katrien H J GaensCasper G Schalkwijk

❮ Previous
Next ❯

Citations

May 28, 2010·Academic Medicine : Journal of the Association of American Medical Colleges·Jakob Ousager, Helle Johannessen
Apr 8, 2011·Acta Ophthalmologica·Inger Christine MunchMichael Larsen
Mar 27, 2010·International Journal of Epidemiology·Merete OslerTorben Jørgensen

❮ Previous
Next ❯

Software Mentioned

SAS
Precard

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
H Lund-AndersenJ Larsen
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
M DiestelhorstR D Hilgers
© 2022 Meta ULC. All rights reserved