Early-Life Adversity and Dysregulation of Adult Diurnal Cortisol Rhythm

The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Arun S KarlamanglaTeresa E Seeman

Abstract

Exposure to life stresses can lead to diminution in the capacity of stress response systems to mount a robust response to new challenges, with blunting of dynamic range-the spread between maximal attainable and minimal resting levels. We investigate the association between early-life adversity and the dynamic range of adult diurnal cortisol secretion. In 35- to 86-year-old adults, cortisol assayed from 16 saliva samples over 4 consecutive days was used to compute diurnal dynamic range and area under the curve (AUC). Economic adversity in childhood was indexed by recalled parental education, family welfare dependence, and perceived financial status; and childhood social adversity by parental separation, death, and abuse. Adjusted for age, gender, and race/ethnicity, both childhood adversities were strongly associated with smaller adult cortisol diurnal dynamic range, but not with AUC. The association with cortisol dynamic range was explained by adult social and economic variables. Early-life adversity appears to leave a long-term imprint on cortisol secretion dynamics, reducing diurnal dynamic range without increasing total secretion. This points to the importance of examining the adaptation capacity of physiological systems whe...Continue Reading

References

Nov 30, 1994·Annals of the New York Academy of Sciences·M F DallmanK S Scribner
Sep 27, 1993·Archives of Internal Medicine·B S McEwen, E Stellar
Apr 16, 1999·Psychosomatic Medicine·J C PruessnerC Kirschbaum
Mar 10, 2001·Psychiatry and Clinical Neurosciences·J A KingJ Brewer
Aug 29, 2001·Development and Psychopathology·M R Gunnar, D M Vazquez
Apr 6, 2005·Psychoneuroendocrinology·Gunther Meinlschmidt, Christine Heim
Nov 9, 2005·Psychoneuroendocrinology·Inka WeissbeckerSandra Sephton
Nov 3, 2006·International Journal of Behavioral Medicine·Elaine SjögrenMargareta Kristenson
Jun 20, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Amy S DeSantisMichelle G Craske
Jul 24, 2007·Psychoneuroendocrinology·Leah LiClyde Hertzman
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ravi VaradhanLinda P Fried
Oct 16, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Eva FriesClemens Kirschbaum
Feb 26, 2010·Biodemography and Social Biology·David M AlmeidaHeather King
Sep 16, 2010·Psychosomatic Medicine·Winfried RiefJoel E Dimsdale
Feb 2, 2011·Experimental Neurology·Timothy J Schoenfeld, Elizabeth Gould
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Meena KumariMika Kivimaki
Jul 16, 2011·Development and Psychopathology·Shelley E TaylorTeresa E Seeman
Oct 25, 2011·Development and Psychopathology·Martie L SkinnerRichard F Catalano
Aug 14, 2012·Brain, Behavior, and Immunity·Sandra E SephtonPaul Salmon
Oct 11, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Susanne R de Rooij
Mar 5, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Anna C PhillipsBrian M Hughes
Feb 5, 2015·Psychosomatic Medicine·Esther M FriedmanTeresa E Seeman
Aug 3, 2016·Psychological Science·Samuele ZilioliGuoxiang Zhao

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Citations

May 22, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Deborah Carr
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Stacy RosenbaumElizabeth A Archie
Nov 19, 2020·Maternal and Child Health Journal·Whitney CowellRosalind J Wright
May 2, 2021·Psychoneuroendocrinology·Samuele Zilioli, Yanping Jiang
Oct 9, 2021·Journal of Public Health Research·Giulia CossuMauro Giovanni Carta

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