Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development.

ELife
Gabriela Manzano NievesKevin G Bath

Abstract

Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB on the development of fear learning and neuronal structures involved in emotional regulation, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA). LB delayed the ability of peri-weanling (21 days old) mice to express, but not form, an auditory conditioned fear memory. LB accelerated the developmental emergence of parvalbumin (PV)-positive cells in the BLA and increased anatomical connections between PL and BLA. Fear expression in LB mice was rescued through optogenetic inactivation of PV-positive cells in the BLA. The current results provide a model of transiently blunted emotional reactivity in early development, with latent fear-associated memories emerging later in adolescence.

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Citations

Sep 6, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yu MaoYuanye Ma
Mar 16, 2021·Current Opinion in Behavioral Sciences·Dylan G Gee
Apr 8, 2021·The European Journal of Neuroscience·Sophia C LevisStephen V Mahler
Apr 30, 2021·Nature Reviews. Neuroscience·Ursula A TooleyAllyson P Mackey

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Prism Graphpad
NIH ImageJ
Ethovision XT
StereoInvestigator
Noldus Ethovision XT
Ethovision
Neurolucida

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