Early-Life Adversity Induces Epigenetically Regulated Changes in Hippocampal Dopaminergic Molecular Pathways

Molecular Neurobiology
Jana C KöhlerKatharina Braun

Abstract

Early-life adversity (ELA) represents a major risk factor for the development of behavioral dysfunctions and mental disorders later in life. On the other hand, dependent on type, time point, and duration, ELA exposure can also induce adaptations, which result in better stress coping and resilience later in life. Guided by the hypothesis that chronic exposure to ELA results in dysfunctional brain and behavior, whereas short exposure to ELA may result in resilience, the behavioral and neurobiological consequences of long-term separation stress (LTSS) and short-term separation stress (STSS) were compared in a mouse model for ELA. In line with our hypothesis, we found that LTSS induced depressive-like behavior, whereas STSS reduced depressive-like behavioral symptoms. We then tested the hypothesis that the opposite behavioral outcomes of the two stress paradigms may be mediated by functional, epigenetically regulated changes of dopaminergic modulation in the hippocampal formation. We found that STSS exposure elevated dopamine receptor D1 (DRD1) gene expression and decreased gene expression of its downstream modulator DARPP-32 (32-kDa dopamine- and cAMP-regulated phosphoprotein), which was paralleled by decreased H3 acetylation at i...Continue Reading

References

Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P RosenfeldS Levine
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y Y Huang, E R Kandel
Mar 29, 2000·Progress in Brain Research·C O LaddP M Plotsky
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 19, 2002·Biological Psychiatry·Xingqun NiJames L Kennedy
Dec 3, 2003·The International Journal of Neuropsychopharmacology·Glenda M MacQueenL Trevor Young
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Per SvenningssonPaul Greengard
Jan 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Todd D Gould, Husseini K Manji
Aug 30, 2006·Neurobiology of Learning and Memory·Sandra SchäbleMichael Gruss
Sep 5, 2006·Neuroscience and Biobehavioral Reviews·Rachel A Millstein, Andrew Holmes
Dec 13, 2006·The European Journal of Neuroscience·Daniela Rüedi-BettschenChristopher R Pryce
Feb 10, 2007·The Journal of Clinical Investigation·Andreas Meyer-LindenbergDaniel R Weinberger
Aug 28, 2007·Journal of Traumatic Stress·David M Lyons, Karen J Parker
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
May 21, 2009·Nature Reviews. Neuroscience·Adriana FederDennis S Charney
Jun 24, 2009·Developmental Neuroscience·Maor KatzDavid M Lyons
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Melly S OitzlE Ronald de Kloet
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyong Ryol KwakHee Jae Lee
Jun 29, 2010·Behavioural Brain Research·Andreas Abraham, Michael Gruss
Sep 21, 2010·Neuroscience and Biobehavioral Reviews·Karen J Parker, Dario Maestripieri
Oct 27, 2010·Nature Neuroscience·Michael J Meaney, Anne C Ferguson-Smith
Nov 19, 2010·Psychopharmacology·Mathias V SchmidtOnno C Meijer
Jan 22, 2011·Neuroscience and Biobehavioral Reviews·Kevin J DudleyTimothy W Bredy
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov
Jun 21, 2011·Stress : the International Journal on the Biology of Stress·T RiconG Richter-Levin
Oct 16, 2012·Nature Neuroscience·Scott J RussoEric J Nestler

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Citations

Feb 23, 2020·Oxidative Medicine and Cellular Longevity·Daniela C WiggerChristiane Waller
Sep 16, 2019·Trends in Endocrinology and Metabolism : TEM·Xin LiZheng Sun
Feb 2, 2021·The FEBS Journal·Praachi TiwariVidita A Vaidya
Apr 4, 2021·Journal of Personalized Medicine·Piotr CzarnyTomasz Sliwinski
May 1, 2021·Journal of Personalized Medicine·Lynn M OswaldCarla L Storr

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Methods Mentioned

BETA
immunoprecipitation
PCR
Protein Assay
histone acetylation
acetylation

Software Mentioned

Gene Tools
GraphPad Prism

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