Early-life adversity programs long-term cytokine and microglia expression within the HPA axis in female Japanese quail

The Journal of Experimental Biology
David J WalkerKaren A Spencer

Abstract

Stress exposure during prenatal and postnatal development can have persistent and often dysfunctional effects on several physiological systems, including immune function, affecting the ability to combat infection. The neuroimmune response is inextricably linked to the action of the hypothalamic-pituitary-adrenal (HPA) axis. Cytokines released from neuroimmune cells, including microglia, activate the HPA axis, while glucocorticoids in turn regulate cytokine release from microglia. Because of the close links between these two physiological systems, coupled with potential for persistent changes to HPA axis activity following developmental stress, components of the neuroimmune system could be targets for developmental programming. However, little is known of any programming effects of developmental stress on neuroimmune function. We investigated whether developmental stress exposure via elevated prenatal corticosterone (CORT) or postnatal unpredictable food availability had long-term effects on pro- (IL-1β) and anti-inflammatory (IL-10) cytokine and microglia-dependent gene (CSF1R) expression within HPA axis tissues in a precocial bird, the Japanese quail (Coturnix japonica). Following postnatal stress, we observed increased IL-1β ...Continue Reading

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Citations

Oct 6, 2020·Brain and Neuroscience Advances·Nichola M Brydges, Jack Reddaway
Sep 23, 2020·Developmental Neurobiology·Charlotte Isabelle Delage, Charlotte Anne Cornil
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Apr 28, 2021·Experimental Gerontology·Myriam P Merz, Jonathan D Turner

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