Early Life Bereavement and Schizophrenia: A Nationwide Cohort Study in Denmark and Sweden

Medicine
Hong LiangJ Li

Abstract

We aimed to examine whether early life bereavement, as indicator of severe stress, was associated with an increased risk of schizophrenia later in life.Based on population registers, we established a cohort of all children born in Denmark (N = 1 686 416) and Sweden (N = 2 563 659) from 1973 to 1997. Children were categorized as exposed if they lost a first-degree relative during the first 18 years of life. Outcome is the first diagnosis of schizophrenia as either inpatient or outpatient. Log-linear Poisson regression models were used to estimate incidence rate ratios (IRRs).A total of 188,850 children (4.6%) experienced death of a first-degree relative from birth to 18 years of age. Compared with unexposed children, those exposed had overall a 39% higher risk of schizophrenia (= 1.39, 95% CI [confidence interval]: 1.32-1.47). The IRR was particularly high if the family member committed suicide (aIRR = 2.11, 95% CI: 1.90-2.34) or died due to an injury or accident (aIRR = 1.44, 95% CI: 1.27-1.63). The IRR of schizophrenia decreased with increasing child's age at bereavement (P < 0.0001). Children who experienced >1 death during the first 18 years of life (aIRR = 1.79, 95% CI: 1.46-2.19) had a higher risk than those with a single ...Continue Reading

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Citations

Jul 10, 2018·Asia-Pacific Journal of Ophthalmology·R Joel WelchCarol L Shields
Mar 30, 2018·Schizophrenia Research and Treatment·Luigi Grillo
Feb 23, 2020·Schizophrenia Bulletin·Stefania TogninLucia R Valmaggia
May 10, 2020·Molecular Psychiatry·Ruyue ZhangSarah E Bergen
Jul 26, 2019·Journal of Clinical Medicine·Supriya MisraCraig Morgan

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