Abstract
To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period. We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and their next of kin. Altogether, 39,857 children were exposed to bereavement during their prenatal life. The main outcome of interest was hospitalization for type-1 diabetes (ICD 8: 249; ICD 10: E10). We found the strongest association for type-1 diabetes among children exposed to traumatic father or sibling deaths (aIRR: 2.03, 1.22-3.38); the association was mainly seen for girls (aIRR: 2.91, 1.61-5.26). We found evidence to suggest that female fetuses exposed to severe prenatal stress are at increased risk for developing type-1 diabetes.
References
Nov 13, 1992·Brain Research·M WeinstockB S McEwen
Feb 1, 1996·Journal of Medical Systems·G L NielsenS Sabroe
Apr 10, 1999·The Orthopedic Clinics of North America·D J Berry
Apr 28, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·P A McKinneyH J Bodansky
May 29, 2002·Diabetologia·E A M Gale
Sep 28, 2002·Diabetes Care·UNKNOWN EURODIAB Substudy 2 Study Group
Nov 28, 2002·Diabetes Care·Jannet SvenssonKnut Borch-Johnsen
Jul 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·D O'ReganM C Holmes
Feb 23, 2008·Diabetologia·C R CardwellC C Patterson
May 2, 2008·American Journal of Obstetrics and Gynecology·Sonja EntringerPathik D Wadhwa
Apr 9, 2009·Nature Reviews. Endocrinology·Décio L EizirikFernanda Ortis
Apr 14, 2009·American Journal of Epidemiology·Thomas HarderAndreas Plagemann
Apr 17, 2009·The New England Journal of Medicine·Patrick ConcannonGerald T Nepom
Jun 2, 2009·Lancet·Christopher C PattersonUNKNOWN EURODIAB Study Group
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Citations
Jun 10, 2014·Indian Journal of Endocrinology and Metabolism·Bharti KalraManash P Baruah
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·Bharti KalraSanjay Kalra
Feb 6, 2013·International Journal of Epidemiology·Naomi H GreeneJorn Olsen
Nov 8, 2012·Reproduction, Fertility, and Development·L A FrankJ G Thompson
Aug 17, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Gregory P Forlenza, Marian Rewers
Dec 14, 2011·Human Reproduction·Florencia Torche, Karine Kleinhaus
Sep 10, 2013·Endocrinology and Metabolism Clinics of North America·François PouwerArie Nouwen
Jan 3, 2012·International Journal of Hygiene and Environmental Health·Jørn Olsen
Jun 23, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Lei Cao-LeiSuzanne King
Jun 12, 2012·Journal of Obesity·Katja Glejsted IngstrupEllen A Nohr
Dec 23, 2014·Psychology, Health & Medicine·L PolloniA Muraro
Feb 9, 2012·Diabetes·Chris R CardwellChris C Patterson
Nov 17, 2011·PloS One·Fang FangCatarina Almqvist
Jul 29, 2016·Seminars in Immunopathology·María Emilia SolanoEva Tolosa
Jan 24, 2017·Journal of Developmental Origins of Health and Disease·C LynchA J Drake
Apr 22, 2019·Journal of Tropical Pediatrics·Silvia BaroncelliMarina Giuliano
Jun 2, 2011·Maternal and Child Health Journal·Cheri PiesSamuel F Posner
Sep 11, 2016·Current Diabetes Reports·Sherman S LeungDanielle J Borg
Oct 10, 2018·Seminars in Immunopathology·Dimitra E Zazara, Petra Clara Arck
May 13, 2018·Acta Diabetologica·Markus LundgrenUNKNOWN DiPiS study group
Nov 11, 2020·Reproductive Biology and Endocrinology : RB&E·Na LiXue-Yi Wang
Jan 7, 2021·Diabetologia·Suzanne Bennett JohnsonUNKNOWN TEDDY Study Group
Dec 18, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sonia ButaliaDoreen M Rabi
Jul 6, 2021·Frontiers in Public Health·Ashley HydeDavid M Olson