Early-life exposure to PM2.5 and risk of acute asthma clinical encounters among children in Massachusetts: a case-crossover analysis

Environmental Health : a Global Access Science Source
Roxana KhaliliVerónica M Vieira

Abstract

Associations between ambient particulate matter < 2.5 μm (PM2.5) and asthma morbidity have been suggested in previous epidemiologic studies but results are inconsistent for areas with lower PM2.5 levels. We estimated the associations between early-life short-term PM2.5 exposure and the risk of asthma or wheeze clinical encounters among Massachusetts children in the innovative Pregnancy to Early Life Longitudinal (PELL) cohort data linkage system. We used a semi-bidirectional case-crossover study design with short-term exposure lags for asthma exacerbation using data from the PELL system. Cases included children up to 9 years of age who had a hospitalization, observational stay, or emergency department visit for asthma or wheeze between January 2001 and September 2009 (n = 33,387). Daily PM2.5 concentrations were estimated at a 4-km resolution using satellite remote sensing, land use, and meteorological data. We applied conditional logistic regression models to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CI). We also stratified by potential effect modifiers. The median PM2.5 concentration among participants was 7.8 μg/m3 with an interquartile range of 5.9 μg/m3. Overall, associations between PM2.5 exposure ...Continue Reading

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Citations

Jul 10, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carrie C SmallcombeFariba Rezaee
Aug 15, 2018·International Journal of Environmental Research and Public Health·Lilin XiongMeng Tang
Jun 21, 2020·International Journal of Environmental Research and Public Health·Andrew Watterson, William Dinan
Jan 23, 2019·Frontiers in Endocrinology·Abby F FleischEmily Oken

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