Early Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years

The Journal of Pediatrics
Don B SandersWayne J Morgan

Abstract

To determine whether severity of lung disease at age 6 years is associated with changes in nutritional status before age 6 within individual children with cystic fibrosis (CF). Children with CF born between 1994 and 2005 and followed in the CF Foundation Patient Registry from age ≤2 through 7 years were assessed according to changes in annualized weight-for-length (WFL) percentiles between ages 0 and 2 years and body mass index (BMI) percentiles between ages 2 and 6 years. The association between growth trajectories before age 6 and forced expiratory volume in 1 second (FEV1)% predicted at age 6-7 years was evaluated using multivariable linear regression. A total of 6805 subjects met inclusion criteria. Children with annualized WFL-BMI always >50th percentile (N = 1323 [19%]) had the highest adjusted mean (95% CI) FEV1 at 6-7 years (101.8 [100.1, 103.5]). FEV1 at 6-7 years for children whose WFL-BMI increased >10 percentile points by age 6 years was 98.3 (96.6, 100.0). This was statistically significantly higher than FEV1 for children whose WFL-BMI was stable (94.4 [92.6, 96.2]) or decreased >10 percentile points (92.9 [91.1, 94.8]). Among children whose WFL-BMI increased >10 percentile points, achieving and maintaining WFL-BMI...Continue Reading

References

Sep 20, 1990·The New England Journal of Medicine·B K Rubin
Jan 15, 1998·The Journal of Pediatrics·M CoreyM Knowles
Mar 20, 1998·The Journal of Pediatrics·A HamoshG R Cutting
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·M S SchechterS C Fitzsimmons
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Ronald L GibsonBonnie W Ramsey
Nov 13, 2003·Archives of Disease in Childhood·I Sermet-GaudelusG Lenoir
Jun 29, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Scott W PowersLori J Stark
Nov 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Andrew T BraunWilliam M Gershan
Mar 3, 2007·Pediatrics·Raj PadmanUNKNOWN Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis
Feb 6, 2010·The Journal of Pediatrics·UNKNOWN Cystic Fibrosis FoundationFrank J Accurso
Jul 3, 2010·Pediatric Pulmonology·Margaret RosenfeldUNKNOWN EPIC Study Group Participating Clinical Sites
Aug 19, 2010·Pediatric Pulmonology·Donald R VanDevanterMichael W Konstan
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Feb 25, 2014·The Journal of Pediatrics·Mark E HauptSusanna A McColley
Jun 12, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sonya L HeltsheNicole Mayer-Hamblett
Aug 20, 2014·The Journal of Pediatrics·Donald R VanDevanterMichael W Konstan

❮ Previous
Next ❯

Citations

May 18, 2016·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Renan Marrichi MauchJosé Dirceu Ribeiro
May 14, 2016·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Jun 5, 2016·Paediatric Respiratory Reviews·Sabariah Noor HarunStefanie Hennig
Jun 9, 2016·Expert Review of Respiratory Medicine·Gabriela R Oates, Michael S Schechter
Jul 30, 2016·Pediatric Clinics of North America·Don B Sanders, Aliza K Fink
Oct 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michael Glenn O'ConnorAdam Seegmiller
Apr 25, 2017·Pediatric Pulmonology·Susanna A McColleyMichael W Konstan
Jun 28, 2016·Therapeutic Advances in Chronic Disease·Claire Edmondson, Jane C Davies
Apr 10, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catherine Larson-Nath, Praveen Goday
Apr 16, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Christopher Smith
Apr 16, 2019·Pediatric Annals·Danielle Goetz, Clement L Ren
Mar 1, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nicolas TerliesnerFreerk Prenzel
Oct 1, 2019·Journal of Pediatric Gastroenterology and Nutrition·Kathleen J HollandWilliam E Bennett
Feb 3, 2018·Pediatric Pulmonology·Rebekah J NevelLisa R Young
Apr 5, 2020·The European Respiratory Journal·Patrick A Flume, Donald R VanDevanter
Apr 18, 2019·Global Pediatric Health·Ting HuangDaishun Liu
Nov 10, 2020·Journal of Pediatric Gastroenterology and Nutrition·Meghana N SatheEric First
Feb 19, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Bernadette J PrenticeJohn Widger
Aug 4, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Ayse Ayzit KilincHaluk Cokugras
Sep 22, 2020·Paediatric Respiratory Reviews·Gwyneth Davies
Jun 21, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sara HenenDhiren Patel
Jun 23, 2020·Journal of the Academy of Nutrition and Dietetics·Catherine M McDonaldMary Rozga
Apr 27, 2021·American Journal of Respiratory and Critical Care Medicine·Cori L Daines, Wayne J Morgan
Jan 22, 2021·Annals of the American Thoracic Society·Don B SandersClement L Ren
Aug 30, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Thida OngBonnie W Ramsey
Sep 10, 2021·Pediatric Pulmonology·Sarah E BauerClement L Ren
Feb 2, 2017·Pediatrics·Michael S StalveySteven M Rowe
Jun 27, 2019·Pediatrics·Aliza K FinkLisa Saiman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.