Early Life Incidence of Gastrointestinal and Respiratory Infections in Children With Gastroschisis: A Cohort Study

Journal of Pediatric Gastroenterology and Nutrition
Jessica BannisterLu Ban

Abstract

Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesized link between the gastrointestinal (GI) tract and immune function, this study explores rates of GI and respiratory infections in children with gastroschisis. We conducted a population-based retrospective cohort study using data from the Health Improvement Network, a large database of UK primary care medical records. We identified children born from 1990 to 2013, and extracted follow-up data to their fifth birthday. We calculate incidence rates (IR) of GI and respiratory tract infections, overall and stratified by age, sex, socioeconomic status, and gestational age at birth, and compared these between children with and without gastroschisis by calculating adjusted incidence rate ratios (aIRR). Children with gastroschisis had a 65% higher IR of GI infection compared to children without (aIRR 1.65, 95% confidence interval [CI] 1.37-1.99, P < 0.001). Children with gastroschisis had a 27% higher IR of all respiratory tract infections (aIRR 1.27, 95% CI 1.12-1.44, P < 0.001) and more than 2-fold increase in lower respiratory tract infections compared to children without the condition (aIRR 2.1...Continue Reading

References

May 1, 1995·Annals of Surgery·W P TunellP C Mantor
Aug 1, 1997·Archives of Disease in Childhood·B W Davies, M D Stringer
Jan 11, 2001·Journal of Pediatric Surgery·K A MolikJ L Grosfeld
Apr 18, 2003·European Journal of Clinical Nutrition·H K F van SaeneD A Lloyd
Dec 24, 2005·The Pediatric Infectious Disease Journal·Natasha B HalasaPeter F Wright
Sep 6, 2008·Clinical and Experimental Immunology·G VighiF Frati
Sep 21, 2010·Journal of Pediatric Surgery·Anthony OwenUNKNOWN BAPS-CASS
May 24, 2011·Journal of Neurogastroenterology and Motility·Eamonn M M Quigley
Nov 9, 2012·Prenatal Diagnosis·Timothy G OvertonMarian Knight
Jun 5, 2013·Frontiers in Neuroscience·Jacqueline M Melville, Timothy J M Moss
Aug 6, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Rachel SokalLaila J Tata
Mar 1, 1996·Pediatric Surgery International·H G LimbachS Lipfert
Aug 21, 2014·JAMA : the Journal of the American Medical Association·Antonia KwanVincent R Bonagura
Oct 5, 2014·Journal of Pediatric Surgery·Emma L HarrisJan E Dickinson
Dec 3, 2014·Seminars in Pediatric Surgery·Piergiorgio Gamba, Paola Midrio
Nov 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Weston T PowellMark A Underwood
Feb 18, 2016·Current Opinion in Pediatrics·Charles M Cotten
May 2, 2016·Seminars in Fetal & Neonatal Medicine·Mei WangSharon M Donovan
Dec 13, 2016·Pediatrics·Shairbanu ZinnaDon Sharkey
Jul 18, 2017·The Journal of Pediatrics·Brenna S FullertonTom Jaksic

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Citations

May 23, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Allison J WuKara L Calkins

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