Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Christopher D CodispotiGrace K LeMasters

Abstract

Nasal eosinophils are a biomarker for allergic rhinitis (AR) and are associated with increased symptom severity. To identify predictors of allergic eosinophilic rhinitis (AER) in early childhood in children at higher risk for chronic allergic respiratory disorders. In the Cincinnati Childhood Allergy and Air Pollution Study, infants born to aeroallergen-sensitized and symptomatic parents were examined and underwent skin prick testing (SPT) annually to 15 aeroallergens from 1 to 4 years of age. Wheal circumferences were traced and scanned and areas were determined by computer planimetry. At 4 years, AER was defined as (1) at least 1 positive aeroallergen SPT result, (2) presence of sneezing and runny nose without a cold or influenza, and (3) nasal eosinophilia of at least 5%. Wheal areas at 1 to 3 years were analyzed for an association with AER compared with children without AR. At 4 years, 487 children completed rhinitis health histories, SPT, and nasal sampling. Ninety-nine children (22.8%) had AR. Thirty-eight children had AER (8.8% of total sample and 38.4% of AR sample, respectively). At 3 years, for every 1-mm(2) increase in Penicillium species (adjusted odds ratio 1.18, 95% confidence interval 1.06-1.32, P = .002) and map...Continue Reading

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Citations

Dec 29, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Gailen D MarshallLeonard Bielory
Jul 9, 2016·Environmental Pollution·Kraiwuth KallawichaHsing Jasmine Chao
Nov 12, 2016·International Journal of Environmental Research and Public Health·Qiao LiJinhua Xu
May 4, 2017·Pediatric Allergy, Immunology, and Pulmonology·Jennifer A KannanPatrick H Ryan
Jan 22, 2019·Mediators of Inflammation·Norihide Murayama, Kikuno Murayama

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