Early-Life Neuronal-Specific Iron Deficiency Alters the Adult Mouse Hippocampal Transcriptome

The Journal of Nutrition
Amanda BarksPhu V Tran

Abstract

Iron deficiency (ID) compromises the developing nervous system, including the hippocampus, resulting in later-life deficits despite iron repletion. The iron-dependent molecular changes driving these lasting deficits, and the effect of early iron repletion, are incompletely understood. Previous studies have utilized dietary models of maternal-fetal ID anemia (IDA) to address these questions; however, concurrent anemia prevents delineation of the specific role of iron. The aim of the study was to isolate the effects of developmental ID on adult hippocampal gene expression and to determine if iron repletion reverses these effects in a mouse model of nonanemic hippocampal neuronal ID. Nonanemic, hippocampus-specific neuronal ID was generated by using a Tet-OFF dominant negative transferrin receptor (DN-TFR1) mouse model that impairs cellular iron uptake. Hippocampal ID was reversed with doxycycline at postnatal day 21 (P21) in a subset of mice to create 2 experimental groups, chronically iron-deficient and formerly iron-deficient mice, which were compared with their respective doxycycline-treated and untreated iron-sufficient controls. RNA from adult male hippocampi was sequenced. Paired-end reads were analyzed for differential exp...Continue Reading

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Citations

Jun 5, 2019·The Journal of Nutrition·Kathleen EnnisRaghavendra Rao
Oct 21, 2018·Pediatric Research·Amanda BarksMichael K Georgieff
Apr 7, 2019·Current Nutrition Reports·Davide Mattei, Angelo Pietrobelli
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Mar 16, 2021·Frontiers in Human Neuroscience·Roza M VlasovaChristopher L Coe
May 15, 2021·Blood Cells, Molecules & Diseases·Timothy M BahrRobert D Christensen
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Sep 21, 2021·Thyroid : Official Journal of the American Thyroid Association·Rodrigo Moreno-ReyesStefanie Vandevijvere

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