Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years

PloS One
Julia DratvaCecilie Svanes

Abstract

Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied. Spirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression. Early life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared t...Continue Reading

References

Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
May 1, 1994·The European Respiratory Journal·P G BurneyD Jarvis
Nov 24, 1999·Thorax·M R Becklake, F Kauffmann
Feb 1, 2002·International Journal of Epidemiology·A SherriffUNKNOWN ALSPAC Study Team. Avon Longitudinal Study of Parents and Children
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·George G ApostolWilliam S Beckett
Aug 5, 2003·The Journal of Allergy and Clinical Immunology·Cecilie SvanesPeter Burney
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Mark N UptonGraham C M Watt
Apr 15, 2004·International Journal of Epidemiology·Benita JacksonUNKNOWN CARDIA Study
May 3, 2005·Obstetrics and Gynecology·Jane Cleary-GoldmanUNKNOWN FASTER Consortium
Oct 7, 2006·American Journal of Respiratory and Critical Care Medicine·Agnes E MarossyH Ross Anderson
Oct 13, 2006·Pediatric Pulmonology·Eli GazalaLena Novack
Feb 12, 2008·Respiratory Medicine·Francesco PistelliGiovanni Viegi
Feb 19, 2008·Paediatric Respiratory Reviews·Kai-Håkon Carlsen, Karin Cecilie Lødrup Carlsen
Sep 20, 2008·The Journal of Clinical Investigation·John W HollingsworthDavid A Schwartz
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Erika von Mutius
Apr 24, 2009·Proceedings of the American Thoracic Society·Fernando D Martinez
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Diane R GoldJames E Gern
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Adit A Ginde, E Rand Sutherland
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Roberto de MarcoUNKNOWN European Community Respiratory Health Survey (ECRHS)
Feb 25, 2011·The New England Journal of Medicine·Markus J EgeUNKNOWN GABRIELA Transregio 22 Study Group
Jul 21, 2011·Current Opinion in Allergy and Clinical Immunology·Anita L KozyrskyjMeghan B Azad
Jan 27, 2012·Seminars in Fetal & Neonatal Medicine·Richard Harding, Gert Maritz
Feb 27, 2013·Therapeutic Advances in Respiratory Disease·Janet Stocks, Samatha Sonnappa
Nov 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D CaudriJ C de Jongste
Oct 6, 2014·Immunology and Allergy Clinics of North America·Debra J PalmerSusan L Prescott
Oct 18, 2014·The European Respiratory Journal·Silvia CarraroEugenio Baraldi
Jan 16, 2015·American Journal of Respiratory and Critical Care Medicine·Victor J ThannickalG R Scott Budinger

❮ Previous
Next ❯

Citations

Jul 22, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keitaro OmoriNobuoki Kohno
Jun 9, 2018·The European Respiratory Journal·Francisco Gómez RealCecilie Svanes
Dec 5, 2019·Annals of the American Thoracic Society·Dinh S BuiShyamali C Dharmage
Apr 29, 2020·The European Respiratory Journal·Sanna Toppila-SalmiJuha Pekkanen
Feb 26, 2020·Journal of Paediatrics and Child Health·Tamara L BlakeMargaret S McElrea
Oct 12, 2016·Cell and Tissue Research·Mariana Matera VerasPaulo Saldiva
Aug 19, 2020·International Journal of Environmental Research and Public Health·Ingrid Nordeide KuiperAne Johannessen
Nov 17, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ling Chen, Graeme R Zosky
Jun 18, 2017·F1000Research·Erik Melén, Stefano Guerra
Apr 20, 2018·Pediatric Pulmonology·Andrew Bush
Mar 14, 2018·International Journal of Epidemiology·Simone AccordiniUNKNOWN Ageing Lungs in European Cohorts (ALEC) Study
Sep 24, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Barbara HammerSusanne Krauss-Etschmann
Sep 4, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Danny WaddenZhiwei Gao
Feb 21, 2019·Clinical Epigenetics·Razia ZakaryaBrian G Oliver
Jun 20, 2021·Paediatric Respiratory Reviews·Andrew Bush
Aug 17, 2021·Acta Medica Lituanica·Andrew BushArūnas Valiulis
Aug 5, 2021·American Journal of Respiratory and Critical Care Medicine·Andrew Bush

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.