Early-life programming of aging and longevity: the idea of high initial damage load (the HIDL hypothesis)

Annals of the New York Academy of Sciences
Leonid A Gavrilov, Natalia S Gavrilova

Abstract

In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging-related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optimizing the early-developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging-related morbidity and mortality, and significant extension of healthy life span.

References

Dec 18, 2001·Journal of Theoretical Biology·L A Gavrilov, N S Gavrilova
Jul 18, 2003·Science of Aging Knowledge Environment : SAGE KE·Leonid A Gavrilov, Natalia S Gavrilova

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Citations

Jul 8, 2010·Biogerontology·Alexios-Fotios A Mentis, Evangelia Kararizou
Feb 12, 2008·Rejuvenation Research·Alexander M Vaiserman
Aug 2, 2014·Journal of Developmental Origins of Health and Disease·A M Vaiserman
Dec 22, 2011·Journal of Aging Research·Leonid A Gavrilov, Natalia S Gavrilova
Aug 13, 2008·Expert Opinion on Biological Therapy·E CeveniniC Franceschi
Feb 3, 2016·Frontiers in Endocrinology·Bronwen MartinStuart Maudsley
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel W BelskyTerrie E Moffitt
Oct 24, 2007·Medical Hypotheses·Walter E Lowell, George E Davis
Jul 13, 2004·Annals of the New York Academy of Sciences·Konstantin KhrapkoYevgenya Kraytsberg
May 16, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Christos ProukakisAnthony H Schapira
Sep 29, 2015·North American Actuarial Journal : NAAJ·Leonid A Gavrilov, Natalia S Gavrilova
Jan 1, 2014·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Ian J RickardDaniel Nettle
Jan 13, 2018·Gerontology·Joshua D PrestonKevin J Pearson
Jan 12, 2016·PloS One·Joost van den HeuvelTobias Uller
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melissa Bateson, Daniel Nettle
Nov 26, 2009·Rejuvenation Research·Leonid A Gavrilov, Natalia Gavrilova
Jan 15, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Terrie E MoffittAvshalom Caspi
Nov 17, 2019·Economics and Human Biology·Ana Lucia Abeliansky, Holger Strulik
May 18, 2010·Journal of Proteome Research·Lei MaoClaus Zabel

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